Methylenedioxymethamphetamine (MDMA) is a phenylethylamine with novel mood-altering properties in humans. MDMA shares the dopamine-releasing properties of amphetamine but has been found to be a more potent releaser of serotonin (5-HT). The present study undertook to determine the relative roles of dopamine and 5-HT release in MDMA-induced locomotor hyperactivity. S-(+)MDMA produced dose-depende...

3. Lcvine S, Pagan J: Effects of ischemia and other procedures on the brain and retina of thegerbil. ExpNeurol 16: 255-262, 1966 4. Kahn K. The natural course of experimental cerebral infarction in the gerbil. Neurology (Minneap) 22: 510-515, 1972 5. Rosenblum WI: Reactivity of cerebral blood vessels after carotid ligation in the gerbil. Stroke 9 (abst) 102, 1978 6. Welch KMA, Chabi E, Buckingh...

Buspirone, a partial agonist of 5-hydroxytryptaminelA autoreceptors, preferentially blocks the presynaptic rather than the postsynaptic D2 dopamine (DA) receptors. Behavioural effects of a wide dose range of buspirone were therefore studied in mice. Buspirone at 0.625 to 5 mg/kg ip induced stereotyped cage climbing behaviour which was antagonized by pretreatment with haloperidol, alpha-methyl-p...

The development of new drugs for the treatment of depression is strategic to achieving clinical needs of patients. This study evaluates antidepressant-like effect and neural mechanisms of four oleanolic acid derivatives i.e. acrylate (D1), methacrylate (D2), methyl fumarate (D3) and ethyl fumarate (D4). All derivatives were obtained by simple one-step esterification of oleanolic acid prior to p...

In the previous paper of this series (Gale & Folkes, 1953c) it was shown that incubation of washed suspensions of Staphylococcus aureus (Micrococcus pyogenes var. aureus) with glucose and [14C]glutamic acid resulted in incorporation of the labelled glutamic acid into the protein fraction of the cells. This process occurred in the absence of demonstrable protein synthesis and underwent considera...

The present study examines the effects of the antidepressant venlafaxine, a dual amine reuptake inhibitor, on (a) in vivo regulation of the densities of high- and low-affinity dihydroalprenolol (DHA) binding sites in the cortex of normal and reserpinized Sprague-Dawley rats and (b) targets beyond the beta adrenoceptor. While venlafaxine (30 mg/kg i.p. b.i.d.) administered for 4 d did not alter ...

Objective: The objective is to observe the treatment effect of electro-acupuncture (EA) on core circadian clock gene Per2 and Bmal1 expression in hypothalamus of sleep-deprivation (SD) rats. Methods: Thirty-two Wistar male rats were randomly divided into 4 groups. Mice in the blank control group did not receive any treatment; the remaining groups were applied with para-chlorophenylalanine (PCPA...

BACKGROUND Serotonin is believed as an important factor in brain function. The role of serotonin in cerebral psycho-patho-physiology has already been well established. However, the function of serotonin antagonist in anesthetized subjects under hyperthermia has not been studied properly. METHODS Experiments were performed in three groups of urethane-anesthetized rats, such as: (i) control gro...