OBJECTIVE The aim of this study was to evaluate the diagnostic accuracy of echo-planar diffusion-weighted magnetic resonance imaging (EP-DWI) and high-resolution computed tomography (HRCT) in the detection and localization of cholesteatoma. MATERIALS AND METHODS Fifty-four patients were prospectively included in this study. Patients with suspected primary or residual cholesteatoma were evalua...

The existence of acquired cholesteatoma has been recognized for more than three centuries; however, the nature of the disorder has yet to be determined. Without timely detection and intervention, cholesteatomas can become dangerously large and invade intratemporal structures, resulting in numerous intra- and extracranial complications. Due to its aggressive growth, invasive nature, and the pote...

OBJECTIVE To examine 10-year results of canal wall down mastoidectomy (CWDM) for acquired cholesteatoma. METHODS Medical records of 136 patients with cholesteatoma who has undergone CWDM in a university hospital and who had a follow-up of at least 10 years were checked. RESULTS During follow-up, 21% of patients had undergone one revision operation and 3% two revisions. The recurrence rate o...

Edfeldt, L. 2013. Middle Ear Cholesteatoma: Surgical Treatment, Follow-up and Hearing Restoration. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 905. 48 pp. Uppsala. ISBN 978-91-554-8672-3. Although middle-ear cholesteatoma is a major topic in otological research, its etiology and pathogenesis remain unclear. Pediatric chol...

Background: Keratinocytes are the predominant cell type in a cholesteatoma, and microRNA (miR)-203a has been shown to be essential for the growth and differentiation of keratinocytes. The regulatory mechanisms of miR-203a and Bmi1-the predicted target of miR-203a that is associated with cholesteatoma-have not been clarified. Methods: Real-time PCR and western blot were carried out for the detec...

OBJECTIVE Routine endoscopic examination during primary surgery decreased the rate of residual cholesteatoma to 18% in our early experience. Based on this, we stopped performing routine second-look surgery in children who were endoscopically free of cholesteatoma at the end of primary surgery. We sought to investigate if second-look procedures after endoscopic-assisted surgery could safely be p...

INTRODUCTION Congenital cholesteatoma of the middle ear is un uncommon and yet not well-defined disease. Only few cases of cholesteatoma in thefossa ovalis with unusual clinical presentation have been reported in medical literature. CASE REPORT We reported a 16-year-old girl with congenital cholesteatoma in the fossa ovalis with minimal clinical presentation. A small mass was found occluding ...

This is a retrospective review of congenital cholesteatoma cases that were managed surgically. There were 5 cases. The age of presentation ranged from 5 to 18 year old. Three patients presented with complication of the disease. Three patients had intact tympanic membrane, two had perforation at the anterior superior quadrant. All patients had cholesteatoma medial to tympanic membrane. Four case...

In this study, 50 patients are included to analyze the incidence of incus erosion in chronic Suppurative otitis media with cholesteatoma. Of these patients 64% were male and 36% were female. Young patients most commonly reported to E.N.T Out Patient Department. The majority of these patients were in between 10 to 30 years and 2% beyond 50 years. Most common presentation was hearing loss, ear di...

Aim: To examine 5 year results of canal wall down mastoidectomy surgery for cholesteatoma. Methods: It was a retrospective study, performed by reviewing medical records of 53 patients with cholesteatoma who had undergone Canal Wall Down Mastoidectomy in ENT department, Lahore Medical & Dental College Lahore/Ghurki trust Teaching Hospital Lahore with a minimum follow-up of 5 years. Results: Duri...