Emerging evidence has revealed that promyelocytic leukemia zinc finger may contribute in several ways to the development and progression of cancer, but no pan-cancer analysis its roles have been undertaken date. Here, we set out use bioinformatics techniques comprehensively investigate expression profiles prognostic significance finger, as well relationship clinic pathological parameters immune...

Renal cell carcinoma (RCC) is one of the most common urological malignancies. In 2016, approximately 62,700 adults (39,650 males and 23,050 females) were diagnosed with RCC in the US and approximately 14,240 individuals died from renal neoplasm [1]. RCC mortality rate can vary between 26% up to 94% according to stage and aggressiveness of the disease [2]. RCC accounts for approximately 3% of so...

OBJECTIVES We studied the role of minor mismatch repair proteins (MMR) human MutL homologue 1 (hMLH1) and human MutS homologue 2 (hMSH2) in the main subtypes of renal cell carcinoma (RCC). METHODS Expression of MMR proteins hMLH1 and hMSH2 were investigated in 166 RCC tumors, containing the main subtypes by immunohistochemistry. Furthermore, each tumor was screened for microsatellite instabil...

Kidney cancer is not a single disease; it is made up of a number of different types of cancer, including clear cell, type 1 papillary, type 2 papillary, chromophobe, TFE3, TFEB, and oncocytoma. Sporadic, nonfamilial kidney cancer includes clear cell kidney cancer (75%), type 1 papillary kidney cancer (10%), papillary type 2 kidney cancer (including collecting duct and medullary RCC) (5%), the m...

Birt-Hogg-Dubé syndrome (BHDS) is an autosomal dominant inherited disorder characterized by clinical features of skin lesions, pulmonary lesions and renal tumor. The gene responsible for this syndrome is located on chromosome 17p11.2 and designated as FLCN. In this article, we review renal tumors associated with BHDS with a focus on clinical and pathobiological aspects. Renal tumors often occur...

OBJECTIVES To assess the potential of CT for characterizing small renal tumors. METHODS 76 patients with <4 cm renal tumors underwent CT examination. The following parameters were assessed: presence of calcifications, densitometry on unenhanced and enhanced scans, washout percentage, urinary tract infiltration, star-shaped scar, and paradoxical effect. RESULTS Calcifications were found in 7...