BACKGROUND Exposure to naphthalene, an International Agency for Research on Cancer (IARC)-classified possible carcinogen and polycyclic aromatic hydrocarbon (PAH), is widespread, though resulting health effects are poorly understood. Metabolites of naphthalene, 1- and 2-naphthol, are measurable in urine and are biomarkers of personal exposure. Chromosomal aberrations, including translocations, ...

the objectives of this study are to investigate chromosomal aberrations of snakehead fish in a leachate-affected reservoir located 100 meters from a municipal landfill which compared to non-affected reservoir. three snakehead fish were collected and chromosomal aberrations were studied using kidney tissue. lead and mercury were measured in water, sediment and snakehead fish from the affected re...

Genomic instability has profound effects on cellular phenotypes. Studies have shown that pluripotent cells with abnormal karyotypes may grow faster, differentiate less and become more resistance to apoptosis. Previously, we showed that microarray gene expression profiles can be utilized for the analysis of chromosomal aberrations by comparing gene expression levels between normal and aneuploid ...

This study evaluated the sensitivities and false positive rates of the screening test using ultrasonographic measurement of thickness of nuchal translucency (NT) with different cut-offs for chromosomal aberration in a Korean population. We included 2,570 singleton pregnancies undergoing ultrasound between 11 weeks and 14 weeks of gestation in this study. We analyzed the sensitivities of NT alon...

Introduction. Chromosomal aberrations are rare but important causes of various movement disorders. In cases disorders associated with dysmorphic features, multiorgan involvement and/or intellectual disability, the identification causative chromosomal should be considered. Aim study. The purpose this article was to summarise clinical findings in six patients dystonia and two parkinsonism identif...

Genomic instability in context of the chromosomal theory * Sir, Cancer cells differ from normal cells in karyotype, cell morphology, invasive or non-invasive growth, development of metastases, primary and acquired drug resistance, and in expression of genes and proteins. The mechanisms of carcinogenesis remain unclear and the prevailing gene mutation theory explaining car-cinogenesis by a seque...

Genetic causes have a considerable involvement in infertility. Well-known examples are some chromosomal translocations or sex-chromosomal abnormalities and Y-chromosome deletions. The most common chromosomal aberrations associated especially with severe oligo- and azoospermia are sex chromosome aneuploidies and chromosomal translocations. Consequently, occurrence of aneuploid embryos will lower...