نتایج جستجو برای: chromosome 10q
تعداد نتایج: 119424 فیلتر نتایج به سال:
Loss of chromosome 10q is a frequently observed genetic defect in prostate cancer. Recently, the PTEN/MMAC1 tumor suppressor gene was identified and mapped to chromosome 10q23.3. We studied PTEN structure and expression in 4 in vitro cell lines and 11 in vivo xenografts derived from six primary and nine metastatic human prostate cancers. DNA samples were allelotyped for eight polymorphic marker...
gliomas and has a median survival of 13.6 months even with aggressive surgical resection, radiation and chemotherapy1. This dismal prognosis is compounded by the failure of novel therapies to yield more than minimal prognostic improvements. A major advance was adjuvant temozolamide treatment but this increased median survival in multi-centre trials by only 2.5 months2-4. Prognostic indicators h...
BACKGROUND Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) at 7 loci influencing glioma risk: rs2736100 (TERT), rs11979158 and rs2252586 (EGFR), rs4295627 (CCDC26), rs4977756 (CDKN2A/CDKN2B), rs498872 (PHLDB1), and rs6010620 (RTEL1). MATERIALS AND METHODS We studied the relationship among these 7 glioma-risk SNPs and characteristics of tumors from 1374 p...
The histological subclassification of gliomas is increasingly assisted by the underlying molecular genetics which has major importance in guiding clinical management of the disease. However, the assessment of several molecular events for improving clinical care remains a challenge. Herein, we report on comparative genomic hybridization (CGH) and immunohistochemical (IHC) assessment of EGFR, PTE...
We conducted a population-based study on glioblastomas in the Canton of Zurich, Switzerland (population, 1.16 million) to determine the frequency of major genetic alterations and their effect on patient survival. Between 1980 and 1994, 715 glioblastomas were diagnosed. The incidence rate per 100,000 population/year, adjusted to the World Standard Population, was 3.32 in males and 2.24 in female...
infertility affects approximately 15% of couples worldwide. within 50% of cases, man provides reproductive function disorders (1). the cause of infertility in men with oligospermia and azoospermia seems to be due to underlying genetic abnormalities (2). chromosomal abnormalities are one of the causes of human infertility as they interfere with spermatogenesis. the frequency of chromosomal aberr...
We describe an 11 year old girl with a de novo unbalanced t(X;10) that resulted in a deletion of Xq26-->Xqter and a trisomy of 10q21-->10qter. Her clinical features were of distal trisomy 10q, but she lacked the cardiovascular and renal malformations observed in duplications of 10q24-->10qter and had only moderate mental retardation. X inactivation was assessed on peripheral blood lymphocytes b...
مقدمه: سندرم متابولیک تجمع خوشه مانند گروهی از فاکتورهای قلبی عروقی شامل چاقی شکمی، دیس لیپیدمی، اختلال در متابولیسم گلوکز و پرفشاری خون می باشد که با افزایش فاکتورهای التهابی نیز همراه است. این مطالعه با هدف اثر مکمل کوآنزیم 10q بر فشار خون و شاخص های التهابی در بیماران مبتلا به سندرم متابولیک انجام شد. روش بررسی: طراحی این مطالعه به صورت کارآزمایی بالینی تصادفی شده دوسوکور بود که با شرکت 50 ن...
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