نتایج جستجو برای: chronic arthritis
تعداد نتایج: 573896 فیلتر نتایج به سال:
It is now generally accepted that CD4+CD25+ Treg cells play a major role in the prevention of autoimmunity and pathological immune responses. Their involvement in the pathogenesis of chronic arthritis is controversial, however, and so we examined their role in experimental antigen-induced arthritis in mice. Depletion of CD25-expressing cells in immunized animals before arthritis induction led t...
INTRODUCTION Cartilage oligomeric matrix protein (COMP) is a homopentameric protein in cartilage. The development of arthritis, like collagen-induced arthritis (CIA), involves cartilage as a target tissue. We have investigated the development of CIA in COMP-deficient mice. METHODS COMP-deficient mice in the 129/Sv background were backcrossed for 10 generations against B10.Q mice, which are su...
Introduction All chronic childhood arthritides of unknown aetiology are termed as Juvenile Idiopathic Arthritis ( JIA). The disease may occur as early as 3–6 years of age, but it occasionally manifests before one year of age. JIA is the most common chronic rheumatic disease in childhood with an incidence of 10-19/100.000 children under the age of 16 years, and it is a major cause of physically ...
A survey of the prevalence of chronic arthritic conditions was carried out on a population of 35,251 patients registered with 29 general practitioners in the highlands of Scotland. Symptomatic osteoarthritis had an overall prevalence of 65 per 1000 but rose from one in 20 of those aged 40-50 years to one quarter of those over 70 years of age. Rheumatoid arthritis was present in 5.5 per 1000 wit...
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