chronic hepatitis b is still a major public health issue despite the successful prophylactic vaccination attempts. chronicity of hepatitis b virus(hbv) is mainly due to its ability to debilitate host's immune system. therefore, major measures have been taken to stop this process and help patients with chronic hepatitis b infection recover from their illness. while satisfactory results have...

background chronic hepatitis b consists of different clinical phases. laboratory and histological assessments can help differentiate the clinical phases of this disease and thus lead to better management. objectives this study was conducted to determine laboratory and histological characteristics of hbeag-negative and hbeag-positive chronic hepatitis b patients. patients and methods in this stu...

The hepatitis-B virus (HBV) is one of the most common chronic pathogens in the world. More than 2 billions of world population have been exposed to this virus and 350 millions of them (5% of world population) are chronic carriers of HBV. One of the most common routes of transmission of this virus is blood products and transfusion . For this reason blood transfusion organization controls all of ...

conclusions the changes of treg and th17 cells and their associated cytokines were related to virological and biochemical responses. results in complete and partial-responders, treg cells frequencies and il-10, tgf-β1, il-23 levels were all decreased significantly after na therapy, while th17 cells and the il-17 levels were increased slightly. treg/th17 ratio was only dramatically declined in c...

background: hepatitis b virus (hbv) causes acute and chronic liver disease worldwide. hbv has eight genotypes (a to h) which is the reflection of its genome with their characteristic geographical distribution. each genotype could have different pathogenic and therapeutic characteristics. there have been few records on hbv genotyping in general population from our region. this study aimed to det...

background: hepatitis-c infection is a major problem in chronically transfused patients. we compared interferon-α (inf-α) monotherapy with combination of inf-α and amantadine in the treatment of β-thalassemia major patients who were chronically infected with hcv.materials and methods: forty six thalassemia major patients who were chronically infected with hcv were randomly divided into two grou...

results the allele and genotype distributions of pnpla3 rs738409 and rs2281135 were not significantly different between the chb and lc groups. after segregation on the basis of sex, no significant correlation between pnpla3 (rs738409 and rs2281135) genotypes/alleles and liver cirrhosis was detected. moreover, none of the haplotypes in pnpla3 (rs738409 and rs2281135) was found to be statisticall...

background serum apoptotic cytokeratine 18 neoepitope m30 (ck-18 m30) and matrix metalloproteinase 2 (mmp-2) have been popular markers for detecting liver fibrosis in recent years. ck-18 is a major intermediate filament protein in liver cells and one of the most prominent substrates of caspases during hepatocyte apoptosis. mmp-2 plays an important role in tissue remodeling and repairing process...