BACKGROUND Mitochondrial dysfunction and defects in oxidative metabolism are a characteristic feature of many chronic illnesses not currently classified as mitochondrial diseases. Examples of such illnesses include bipolar disorder, multiple sclerosis, Parkinson's disease, schizophrenia, depression, autism, and chronic fatigue syndrome. DISCUSSION While the majority of patients with multiple ...

We report a 44 year old man who developed external ophthalmoplegia and predominantly respiratory, truncal and bulbar weakness with brisk reflexes, histological evidence of an inflammatory myopathy and a high titre of acetylcholine receptor antibodies, one month after starting hydroxyurea and allopurinol for chronic myeloid leukaemia. The temporal relationship suggests a possible association bet...

The two immunoinflammatory disorders, rheumatoid arthritis (RA) and Periodontitis (PD) are characterized by synovitis, joint damage, alveolar bone degradation, triggered certain inflammatory mediators leukocyte invasion, respectively. Rheumatoid is an infectious disorder which attacks changed self-epitopes thus affects 1% of the human population, whereas 11% worldwide population aged afflicted ...

Osteoarthritis (OA) is a common degenerative disorder and accompanied by numerous pain symptoms. With increased age, individuals develop chronic inflammatory status, pro-inflammatory cytokines as well mediators contribute to the progression of OA. However, no desirable remedies have been completely able inhibit OA or safely provide effective symptomatic relief. Natural component extracts dietar...

Asthma is a multifactorial, chronic inflammatory disease of the airways. The knowledge that asthma is an inflammatory disorder has become a core fundamental in the definition of asthma. Asthma's chief features include a variable degree of air-flow obstruction and bronchial hyper-responsiveness, in addition to the underlying chronic airways inflammation. This underlying chronic airway inflammat...

Data show that up to 38.2% of the European population have a mental disorder and that recurrent depressive disorder (rDD) is among the most commonly diagnosed disabling diseases. Over the last few years, neurocognitive impairments in rDD have become a new research front focusing on the role of cognitive decline during the course of rDD and in relation to its clinical presentation and prognosis....

Obesity is associated with several co-morbidities including chronic pain. Systemic low-grade inflammation and dysregulation of pro-inflammatory cytokines have been proposed to underlie these phenomena. This study characterized pain inflammation, levels the cytokine visfatin, in a rodent model obesity, investigated whether treatment visfatin inhibitor, FK866, has anti-inflammatory and/or analges...

18F-labeled fluoro-2-deoxyglucose positron emission tomography/ computed tomography (18F-FDG PET/CT) is an important imaging modality in the clinical workup of patients with chronic inflammatory disorders which present quite often with a fever of unknown origin. Sarcoidosis is a multisystem chronic inflammatory disorder with a wide clinical spectrum that can involve different organs. The diagno...