MicroRNAs (miRNAs) are small RNA molecules that function to modulate the expression of target genes, playing important roles in a wide range of physiological and pathological processes. The miRNAs in body fluids have received considerable attention as potential biomarkers of various diseases. In this study, we compared the changes of the plasma miRNA expressions by acute liver injury (hepatocel...

We reported here a case of anticoagulant-related nephropathy (ARN) in an elderly patient with background history chronic kidney disease (CKD-stage 4, estimated glomerular filtration rate (eGFR) <24 ml/min). He presented acute injury on (AKI/CKD) eGFR 9 ml/min and serum creatinine 6.0 mg/dl.

Although previous studies reported the involvement of the TLR4-TRIF pathway in alcohol-induced liver injury, the role of TLR2 and TLR9 signaling in alcohol-mediated neutrophil infiltration and liver injury has not been elucidated. Since alcohol binge drinking is recognized to induce more severe form of alcohol liver disease, we used a chronic-binge ethanol-feeding model as a mouse model for ear...

AIMS (1) To investigate whether a daily acute:chronic workload ratio informs injury risk in Australian football players; (2) to identify which combination of workload variable, acute and chronic time window best explains injury likelihood. METHODS Workload and injury data were collected from 53 athletes over 2 seasons in a professional Australian football club. Acute:chronic workload ratios w...

Clinical observations have demonstrated a link between chronic pain and increased ischemic heart disease mortality, but the mechanisms remain elusive. Reactive aldehydes have recently been confirmed as a new player in pain pathologies, while our previous study demonstrated that reactive aldehydes (4-HNE) induced carbonyl stress contributing to myocardial ischemic intolerance. The aim of this st...

Thymosin beta 4 (Tβ4) was previously shown to reduce infarct size and improve contractile performance in chronic myocardial ischemic injury via two phases of action: an acute phase, just after injury, when Tβ4 preserves ischemic myocardium via antiapoptotic or anti-inflammatory mechanisms; and a chronic phase, when Tβ4 activates the growth of vascular or cardiac progenitor cells. In order to di...

Chronic lateral ankle instability (CAI) is defined as the occurrence of recurrent bouts instability. Clinical examination should be supplemented by a complete, directed imaging assessment. Imaging occurred simple comparative AP and weight-bearing X-ray, stress X-rays, ultrasound, CT arthrography MRI. Arthroscopic classification chronic stable ankle, moderate instability, severe global Managemen...