Background and purpose - Acute kidney injury (AKI) is associated with increased short-term and long-term mortality in intensive care populations and in several surgical specialties, but there are very few data concerning orthopedic populations. We have studied the incidence of AKI and the prevalence of chronic kidney disease (CKD) in an elective population of orthopedic patients undergoing prim...

Chronic Kidney Disease (CKD) is widely prevalent in the elderly population. The recent "Kidney Disease: Improving Global Outcomes (KDIGO) 2012 Clinical Practice Guideline on the Evaluation and Management of CKD" builds on the previous Kidney Disease Outcomes Quality Initiative (KDOQI) guideline and addresses many of its gaps. However, older adults with CKD have unique characteristics that may n...

This article reviews the association of chronic renal disease and pregnancy. Included are discussions of physiological changes in a normal pregnancy and abnormalities encountered during pregnancy in a patient with chronic kidney disease (CKD), in terms of the effect of pregnancy on kidney disease as well as the effect of kidney disease on the pregnancy. Management plan is discussed with approac...

INTRODUCTION The last few years have seen a phenomenal increase in the prevalence of chronic kidney disease (CKD). Cardiovascular disease remains the most important cause of death in these patients.The present study was conducted to evaluate endothelial dysfunction in CKD patients as compared with controls. METHODS Thirty-five patients of CKD and 32 age and sex-matched controls were included ...

Objective: Chronic kidney disease (CKD) increases the risk of cardiorenal (CR) events such as progression leading to regular hemodialysis, rehospitalization for heart failure (re-HF), and death from cardiac or renal cause (CR death). This study aimed assess rates late adverse CR among patients with CKD following transcatheter aortic valve replacement (TAVR).

Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is a newly defined syndrome encompassing patients with chronic kidney disease that have a triad of biochemical alterations in calcium, phosphorus and parathyroid hormone, vascular calcification, and bone abnormalities. Here we describe a novel Cy/+ rat model of slowly progressive kidney disease spontaneously developing the three components ...

Abstract Background Estimated glomerular filtration rate (eGFR) is a key determinant of eligibility for many life-saving therapies in HFrEF. Recently, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) provided new equations based on creatinine (CKD-EPIcr), cystatin C (CKD-EPIcys) or both (CKD-EPIcyscr) that do not include race. These may reclassify individuals, irrespective race, ...

Oxidative stress plays a key role in numerous disease processes including chronic kidney disease (CKD). In general, oxygen metabolism leads to the formation of reactive oxygen species (ROS) dangerous to cells. Although enzymes and low-molecular-weight antioxidants protect against ROS, chronic imbalances of formation and elimination can eventually overwhelm endogenous defenses leading to deleter...

Anemia and metabolic bone disease accompany chronic kidney disease (CKD), and worsen as CKD progresses. It is likely that both processes contribute to the increased morbidity and mortality seen in CKD. This paper briefly reviews the pathogenesis and diagnosis of anemia and bone disease in CKD, and summarizes recent consensus guidelines for treatment.

There is an increased prevalence of cardiovascular disease- (CVD-) related mortality in patients with chronic kidney disease (CKD). Endothelial dysfunction is a primary event in the development of atherosclerosis and hypertension and likely contributes to the elevated cardiovascular risk in CKD. Endothelial dysfunction has been shown to occur in the peripheral vasculature of patients with both ...