il study of enzyme inhibitors designed to obtain information on the possible physiological significance of blood antiprotease has produced a number of simple fundamental reactions which have hitherto not been reported. It is the purpose of this paper to record these reactions for the possible benefit of others who may wish to investigate them further. Materials-The t,rypsin, chymotrypsin, and t...

Diabetic nephropathy (DN) remains the most common cause for end stage renal disease (ESRD) as the burden of diabetes increases worldwide [13]. The mechanisms of DN are not very clear, but the extensive investigation has documented the key role of the rennin angiotensin aldosterone system (RAAS) in the pathogenesis and pathophysiology of DN [4]. Accordingly, blockade of the RAAS is first-line th...

In this study, the enzyme-induced and acid coagulation of raw milk samples were investigated, these two processes monitored by determining changes in dielectric rheological behavior to see if any correlations could be found between properties. For experiments, 250 cm3 sample industrial chymosin used, during coagulation, thermophile yogurt culture was added same amount milk. The apparent viscosi...

The tryptic peptides from human pepsin and gastricsin were purified and their sequences were determined. The sequence of 27 residues at the COOH-terminal end of human pepsin was found to be: -Ile-Leu-Gly-Asp-Val-Phe-Ile-ArgGln-Phe-Tyr-Thr-Val-Phe-Asp-Arg-Ala-Asn-Asn-GlnVal-Gly-Leu-Ala-Pro-Val-Ala. The sequence of 19 residues at the COOH-terminal end of human gastricsin was found to be: -Gln-Phe...

Although calcium is essential for the formation of thrombin, it can be recovered quantitatively from formed horse thrombin without affecting its coagulating activity. Citrate also has no significant effect. As stated in the text, this does not exclude the possibility that thrombin is actually a calcium compound present in minute concentration; but confirming the results of Hammarsten, it does s...

In the present study, we evaluated the involvement of the rennin-angiotensin system (RAS) in the control of the blood pressure (BP), baroreceptor-mediated bradycardia and the reactivity of caudal ventrolateral medulla (CVLM) neurons to Ang II and to AT(2) receptor antagonist in sedentary or trained renovascular hypertensive rats. Physical activity did not significantly change the baseline mean ...

The properties of the paracasein and casein preparations studied are compared in Table VI. See PDF for Structure I. Casein retains its characteristic solubility in NaOH: (1) after being exposed to a high degree of alkalinity during its preparation, (2) when recovered from partially hydrolyzed solutions in NaOH, and (3) after being kept for a prolonged time at the isoelectric point at 5 degrees ...

Examination of the kinetic parameters for the hydrolysis, by acid proteinases, of a single peptide bond (between p-nitro-L-phenylalanyl and L-phenylalanyl) in a series of oligopeptides has shown that secondary interactions are important factors in determining the catalytic efficiency. Comparison of the action of highly purified pepsinlike enzymes (Rhizopus proteinase, Mucor proteinase, rennin) ...

The complex chemical nature of Indian cobra (Naja naja) venom was indicated by Ganguly & Malkana (1936) and Ganguly (1937), who reported its percentage composition as follows: total protein 87-56, globulin 20*31, albumin 39-69, primary proteose 11 31, secondary proteose 16-81. In addition to proteins, the venom was found to contain cholesterol, phospholipins, inorganic substances and colouring ...