Cardiovascular disease (CVD) is a major comorbidity in chronic obstructive pulmonary disease (COPD). Although the mechanism of its development remains largely unknown, it appears to be associated with cigarette consumption and reduced lung function. Therefore, the aim of this study was to investigate the potential link between water-soluble cigarette smoke extract (CSE)-induced endothelial dysf...

ular for lung endothelial cells, is disrupted by the toxic effect of chronic cigarette smoke in genetically susceptible patients, thus resulting in centrilobular emphysema. Specifically, we hypothesize that disappearance of lung alveoli resulting in centrilobular emphysema occurs by apoptosis after decreased expression or activity of lung vascular endothelial cell growth factor (VEGF) or its re...

This study sought to determine the potential role of microRNAs (miRNAs) in the detrimental effects of cigarette smoke on angiogenesis and neovascularization. Using large-scale miRNA profiling and qRT-PCR analyses, we identified let-7f as a pro-angiogenic miRNA which expression is significantly reduced in HUVECs treated with cigarette smoke extracts (CSE), and in the ischemic muscles of mice tha...

Previous studies demonstrated that CSE induces oxidative stress and its consequences on isolated mitochondria obtained from lung, heart and brain which may provide insight into the role of CSE in human health and disease. The present study was carried out to further characterize and compare toxic effect of CSE extract on isolated mitochondria obtained from either a directly contacting tissue (i...

Cigarette smoke is a common environmental insult associated with increased risk of developing airway diseases such as wheezing and asthma in neonates and children. In adults, asthma involves airway remodeling characterized by increased airway smooth muscle (ASM) cell proliferation and increased extracellular matrix (ECM) deposition, as well as airway hyperreactivity. The effects of cigarette sm...

various substances in cigarette smoke including nicotine have been shown to promote/induce cancer cell proliferation. since cotinine has a longer half life and stability in the blood, it has become the preferred biomarker for cigarette smoking exposure. seventy-three gastric cancer patients were included in this study. the tumor tissues were stained with h and e for pathological evaluation. the...

abstract background: research suggests that factors in the environment are major determinants of health behavior for populations. this cross-sectional study used a combination of quantitative and qualitative data collection methods to determine the prevalence of smoking and identify the possible associations between smoking and environmental variables among school pupils in iran. methods: a sel...

objective: according to the fact that university students are role models for the whole society, this study was performed to evaluate reasons of and attitudes toward cigarette smoking among iranian university students. methods: this study was performed as a cross-sectional self-reported questionnaire based study among university students of kerman city of iran. our questionnaire was attributed ...

BACKGROUND Cigarette smoke is the leading risk factor for the development of chronic obstructive pulmonary disease (COPD) an inflammatory condition characterised by neutrophilic inflammation and release of proinflammatory mediators such as interleukin-8 (IL-8). Human airway smooth muscle cells (HASMC) are a source of proinflammatory cytokines and chemokines. We investigated whether cigarette sm...

ôbjective: previous studies reported that individuals with parkinson’s disease are less likely to have smoking history and it seems that nicotine has a neuroprotective effect. the authors have conducted a case-control retrospective study to determine if there is an association between cigarette smoking and parkinson’s disease. methods: ïn a matched case-control study, 92 individuals with parkin...