Phosphopeptide pTyr-Glu-Glu-Ile (pYEEI) has been introduced as an optimal Src SH2 domain ligand. Peptides, Ac-K(IDA)pYEEIEK(IDA) (1), Ac-KpYEEIEK (2), Ac-K(IDA)pYEEIEK (3), and Ac-KpYEEIEK(IDA) (4), containing 0-2 iminodiacetate (IDA) groups at the N- and C-terminal lysine residues were synthesized and evaluated as the Src SH2 domain binding ligands. Fluorescence polarization assays showed that...

In this article, a novel structure of photonic crystal fiber with nearly zero ultra-flattened chromatic dispersion and ultra-low confinement loss is presented. By replacing the circular air-holes of two first rings with the elliptical air-holes, a fiber with outstanding features of chromatic dispersion and confinement loss is designed. The proposed structure is optimized for operating in a wide...

In this paper, we derive a capacity inner bound for a synchronous Gaussian Z channel with intersymbol interference (ISI) under input power constraints. This is done by converting the original channel model into an n-block memoryless circular Gaussian Z channel (n-CGZC) and successively decomposing the n-block memoryless channel into a series of independent parallel channels in the frequency dom...

Peptide-based structures can be designed to yield artificial proteins with specific folding patterns and functions. Template-based assembly of peptide units is one design option, but the use of two orthogonal self-assembly principles, oligonucleotide triple helix and a coiled coil protein domain formation have never been realized for de novo protein design. Here, we show the applicability of pe...

The problem of direction arrival (DOA) estima- tion with a circular microphone array has been addressed classical source localization methods, such as the model-based methods and parametric methods. These have an ad- vantage in estimating DOAs blind manner, i.e. no (or limited) prior knowledge about sound sources. However, their performance tends to degrade rapidly noisy reverberant environment...

Components and component-orientation is often depicted as the next step after object orientation. A huge number of proposals and implementations of component models, frameworks, and standards are available nowadays, leading to many different definitions of the term software component. Additionally, often the terms component, object, object framework – to mention only the most evident are not cl...