Flow chemistry was initially used for speed to early phase material delivery in the development laboratories, scaling up chemical transformations that we would not or could scale batch safety reasons. Some examples included a Newman Kwart Rearrangement, Claisen rearrangement, hydroformylation, and thermal imidazole cyclization. Next, flow enable safe of hazardous chemistries manufacturing plant...

Members of the GE81112 family are interesting candidates for development antibiotics. The configuration OH group on pipecolic acid moiety plays a pivotal role in antibiotic activity. To investigate stereoselectivity corresponding hydroxylase GetF, involved biosynthetic pathway, we synthesized two deuterium-labeled diastereomers highly stereoselective fashion via chelate-enolate Claisen rearrang...

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A concise synthesis of forbesione (1) and desoxymorellin (3) is presented. Central to the strategy is a biomimetic Claisen/Diels-Alder/Claisen reaction cascade that proceeds in a regioselective manner and produces the desired scaffold exclusively. The observed regioselectivity and product distribution of the Claisen/Diels-Alder/Claisen reaction are attributed to the electronic effects of the xa...

The fused 2-vinyl or 2-phenyl substituted cyclobutanones 4 undergo stereoselective ring openings by the action of alkoxide ions (t-BuO(-) or MeO(-)) to produce novel vicinally disubstituted cycloalkene derivatives 5 and 6 in moderate to high yields. The ring cleavage usually occurs with complete regioselectivity. The accessibility of γ,δ-unsaturated ester or acid derivatives makes this transfor...