Study sample sizes in human genetics are growing rapidly, and in due course it will become routine to analyze samples with hundreds of thousands, if not millions, of individuals. In addition to posing computational challenges, such large sample sizes call for carefully reexamining the theoretical foundation underlying commonly used analytical tools. Here, we study the accuracy of the coalescent...

Ehrlich's days were filled with an excited, enthusiastic concentration on his scientific ideas and plans for research. He made three great contributions: (1) Invented modern cytological staining methods based on chemical affinities betwen dyes and cell structures; (2) His studies of Immunology won him a Nobel prize in 1908; (3) He invented scientific chemotherapy. In well-planned research he an...

Johnson and Wright ~hereafter J&W! claim, in their brief communication entitled “Reply to Philipona and O’Regan” that there are various difficulties in the reasoning in Philipona and O’Regan’s ~2006! paper entitled “Color naming, unique hues and hue cancellation predicted from singularities in reflection properties,” which was published in this journal in 2006. These difficulties supposedly pre...