Introduction Oral clefts including cleft palate (CP), cleft lip with or without cleft palate (CL/P) and cleft lip (CL) are considered as common congenital anomalies (1). Oral clefting has reported with an incidence rate of 0.5-2.5 per 1000 live births worldwide, although ethnical and different geographical area can be the significant affect on the incidence rate (2-4) and widely among different...

Nonsyndromic oral clefts are considered a problem of public health in Brazil, presenting a multifactorial etiology that involves genetic and environmental components, such as maternal alcohol consumption. Several candidate genes have been investigated to identify some association with nonsyndromic clefts risk. The epidermal growth factor (EGF) gene is implicated in the normal craniofacial devel...

Learning Objectives: After studying this article, the participant should be able to: 1. Describe the differing types of congenital clefting defects that extend outward from the perioral region. 2. Define the sites of anatomical disruption and deformities that these types of facial clefts cause. 3. Describe the cause and incidence, if known, of orofacial clefts and their inheritance/transmission...

Facial clefts are extremely rare congenital deformities and there are only a few technique reports for surgical reconstruction of clefts in the literature. In this article, we report a Tessier no. 3 incomplete cleft reconstruction with alar transposition and irregular Z-plasty in a 2-year old female patient.

INTRODUCTION A cleft lip with or without a cleft palate is one of the major congenital anomalies observed in newborns. This study explored the risk factors for oral clefts in Gorgan, Northern Iran. MATERIALS AND METHODS This hospital-based case-control study was performed in three hospitals in Gorgan, Northern Iran between April 2006 and December 2009. The case group contained 33 newborns wit...

BACKGROUND Clefts of the lip and palate are the most common significant congenital birth anomaly of the orofacial region. The condition may vary from a minor easily correctable cleft to a significant functional and cosmetic incapacitation. This is the first epidemiological study of orofacial clefts in the Negev region in Israel. OBJECTIVES To establish the frequency of cleft lip and palate in...

OBJECTIVES The aim of this study was to investigate whether there is an association between enlarged nuchal translucency (NT) and orofacial clefts. METHODS The pregnancy outcome of women who underwent an NT measurement between January 2000 and November 2008 was reviewed. All orofacial clefts detected prenatally and postnatally in karyotypically normal fetuses/infants were reviewed and a disti...

background: the purpose of this study was to describe the association of mthfr gene single nucleotide polymorphisms (c677t and a1298c) and maternal supplementary folate intake with orofacial clefts in the iranian population. methods: in this case-control study, peripheral venous blood was taken from 65 patients with orofacial clefts and 215 unaffected controls for dna extraction and kept in edt...