Syndromes of schizophrenia, bipolar disorder, obsessive-compulsive substance use disorders and Alzheimer's dementia are highly heritable. About 10-20% subjects have another affected first degree relative (FDR), thus represent a 'greater' genetic susceptibility. We screened 3583 families to identify 481 with multiple members, assessed 1406 individuals in person, collected information systematica...

OBJECTIVE The authors sought to demonstrate that schizophrenia is a heterogeneous group of heritable disorders caused by different genotypic networks that cause distinct clinical syndromes. METHOD In a large genome-wide association study of cases with schizophrenia and controls, the authors first identified sets of interacting single-nucleotide polymorphisms (SNPs) that cluster within particu...

Neuroendocrine tumours may be either benign or malignant tumours, and have the ability to synthesise and secrete biologically active substances characteristic of the cell of origin that can cause distinct clinical syndromes. The term 'paraneoplastic syndromes' (PNSs) is used to denote syndromes secondary to substances secreted from tumours not related to their specific organ or tissue of origin...

This perspective article aims at addressing the potential commonalities associated with chronic obstructive pulmonary disease (COPD) and two metabolic fatty liver syndromes: nonalcoholic (NAFLD) (associated) (MAFLD). To this end, we briefly review definitions burdens of COPD NAFLD highlight differences in diagnostic criteria MAFLD. We also critically discuss recent line research trying to ident...