BACKGROUND Bone is an uncommon site of metastasis in patients with advanced hepatocellular carcinoma (HCC). Therefore, there are few studies concerning the natural history of bone metastasis in patients with HCC. PATIENTS AND METHODS Data on clinicopathology, survival, skeletal-related events (SREs), and bone-directed therapies for 211 deceased HCC patients with evidence of bone metastasis we...

BACKGROUND Bone metastasis represents an increasing clinical problem in advanced renal cell carcinoma (RCC) as disease-related survival improves. There are few data on the natural history of bone disease in RCC. PATIENTS AND METHODS Data on clinicopathology, survival, skeletal-related events (SREs), and bone-directed therapies for 398 deceased RCC patients (286 male, 112 female) with evidence...

This study is to identify the spectrum of Epstein-Barr virus (EBV)-positive lymphoproliferative diseases (LPD) and relationships between these diseases in Korea. The EBV status and clinicopathology of 764 patients, including acute EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH), chronic active EBV (CAEBV) infections, B-LPD arising in chronic latent EBV infection, T & natural killer ...

OBJECTIVE : Oral squamous-cell carcinoma (OSCC) accounts for >90% of oral cancers affecting adults mostly between the fourth to seventh decades of life. The most common OSCC treatment is concomitant chemoradiotherapy (CCRT) having both loco-regional and distant control, but CCRT has acute and chronic toxic effects on adjacent normal tissue. This study aimed to determine the side effects of CCRT...

Small-cell lung carcinoma (SCLC) is a type of lung cancer with neuroendocrine differentiation and a poor prognosis that is widely believed to arise in the central lung. Thyroid transcription factor-1 (TTF-1) is a peripheral marker of lung adenocarcinoma that is also highly expressed in SCLC. In this study, we examined whether SCLC is really a central-type tumor and the relationship between tumo...

OBJECTIVES To investigate the clinicopathologic characteristics of patients with immunoglobulin G4-related chronic sclerosing sialadenitis (IgG4-RCSS), a recently recognized disease. STUDY DESIGN Case series with chart review and pathology study. SETTINGS Tertiary care hospital. SUBJECTS AND METHODS We evaluated chronic sialadenitis specimens obtained over 11 years using pathologic examin...

Hematol Oncol Stem Cell Ther 1(4) October 2008 hemoncstem.edmgr.com 241 Monoclonal extramedullary plasmacytoma (EMP) is a rare plasma cell tumor. The dil agnosis is based on a mass of clonal plasma cells separate from bone or bone marrow without evil dence of occult disease elsewhere. It occurs in the upper aerodigestive tract in more than 80% of patients, most often in the nasal cavity, parana...

BACKGROUND Human papilloma virus infection is associated with genesis and malignant potential of cervical cancer. E6 and E7 oncogens are known to bind to p53 and retinoblastoma gene products, abrogating their functions as tumor suppressors, leading to an abnormal cell cycle machinery. Roles of the p53 homolog p63 have also been postulated, E6 expression leading to TAp63b degradation allowing an...

Gastric cancer (GC) is the fourth most common malignant tumor worldwide and the second highest in developing countries (Jemal et al., 2010; Parkin, 2001; Siegel et al., 2012). It also ranks as the second leading cause of cancer death worldwide (Camargo et al., 2012; Yin et al., 2012). Moreover, nearly 47% of worldwide gastric cancer cases occur in China alone (Shen et al., 2013b). Currently rad...

AIM Over-expression of some genes, such as MDR1, can increase the level of chemotherapy drug afflux and limit the effectiveness of treatment. We aimed to investigate the effect of MDR1 polymorphisms on its expression level and related characteristics in Iranian colorectal cancer patients. METHODS Tumor, normal mucosal tissue and blood samples from CRC patients and blood samples from healthy c...