Topical corticosteroids have long been the chronic stage in the treatment of steroid responsive dermatitis. Creams containing 0.05% w/w Clobetasol-17-propionate (CP) as active ingredient are categorized as super potent class I topical dermatological corticosteroids. For the drug molecule to reach the cutaneous microcirculation, enhance, the systemic circulation, have to transverse both the lipo...

With the institution of antiretroviral therapy, psoriasis can be controlled with topical treatments, such as clobetasol and calcipotriene and ultraviolet light. Before adequate immune reconstitution under antiretroviral therapy occurs or in cases of complex or more severe psoriasis, treatment with the retinoid agent acitretin at 10 to 25 mg/d can be considered; it should be noted that this agen...

CASE A 68-year-old woman presented with a pruritic, blistering rash. Three months prior, she had developed itchy lesions on her hands and feet, spreading to her chest and abdomen. For the past week, she had developed painful, tense blisters. The patient had seen her primary care doctor at symptom onset and failed to improve with topical clobetasol proprionate and hydroxyzine. She took amlodipin...

Proliferative and necrotising otitis externa (PNOE) is a very rare disease affecting the ear canals and concave pinnae of kittens. This report describes a 5-month-old cat with PNOE. Histopathological examination confirmed the diagnosis. Treatment was initiated with local injection of methylprednisolone acetate into the lesions. The cat was subsequently treated with clobetasol propionate cream, ...

Abstract Objective: Glucocorticoid (GC) treatment suppress the hypothalamic-pituitary-adrenal axis, which may lead to tertiary adrenal insufficiency. This study aimed investigate prevalence of insufficiency among patients with oral lichen planus treated topical GC (clobetasol propionate) in cavity, a standard option for this condition. Methods: In cross-sectional study, we included 24 receiving...

Objective: Formulation and evaluation of clobetasol-17-propionate-loaded carboxymethyl chitosan nanoparticle. Psoriasis is a chronic skin disorder caused due to the autoimmune factors. It has detrimental psychological physiological impact on patients emergence apparent skin. The systemic therapy with anti-psoriatic drugs such corticosteroids, immunosuppressant, gene suppressors causes severe si...

Background: The human cytochrome P450 (CYP) CYP3A4 and CYP3A5 enzymes metabolize more than half of marketed drugs. They share high structural substrate similarity are often studied together as CYP3A4/ 5. However, they preferentially different clinically prescribed Moreover, the differential distribution expression levels in both normal diseased tissues can aggravate toxicity induce resistance d...