Introduction This study aimed to investigate the biological role of microRNA 93 (miR-93), a novel tumor-related miRNA, in human hepatocellular carcinoma (HCC) and elucidate potential molecular mechanisms involved. Material methods Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted determine expression miR-93 HCC tissues cell lines. The log-rank test Kaplan-Meier survival a...

TRPM8 is a Ca2+-permeable nonselective cation channel belonging to the melastatin sub-group of the transient receptor potential (TRP) family. TRPM8 is aberrantly overexpressed in a variety of tumor entities including glioblastoma multiforme where it reportedly contributes to tumor invasion. The present study aimed to disclose further functions of TRPM8 in glioma biology in particular upon cell ...

6-precursor acute lymphoblastic leukemia bone marrow specimens that contained subpopulations of cells with immunophenotypes corresponding to early (CD34) and late (CD20) and (CD22) stages of normal B-cell differentiation were studied. Subpopulations of cells were isolated according to immunophenotype and then analyzed by both a clonogenic assay and molecular genetic methods. Clonal equivalence ...

Thailand's second-leading cause of death is lung cancer. Thai indigenous herbal plants are sought after as an alternative treatment against This work aimed to examine cytotoxic, antiproliferative and antimigratory capacities different parts Streblus asper (SA) from northeastern Thailand on A549 cancer cells. Plant leaves, twigs, bark wood were used for ethanolic extraction by maceration. The hi...

Cervical cancer is second only to breast in terms of incidence; however, it the most lethal form among Thai women due asymptomatic nature its early stages. This work aimed examine cytotoxic and antiproliferative capacities Rhinacanthus nasutus (RN) Acanthus ebracteatus (AE) extracts against human cervical cells (HeLa). Plant leaves were used for ethyl acetate extraction. The antioxidant assays,...

Polynucleotides (PN) have long been known as an effective supportive therapy for wound healing. The present study investigated whether a hydrogel formulation containing PN and hyaluronic acid (PN + HA) could promote healing in vitro model of gingival fibroblasts. promoted cell growth viability assessed by different assays, HA, though not significantly further increasing compared to PN, supporte...

/V-Nitrosomethylurea-induced rat mammary tumors were grown in vitro using the clonogenic soft agar technique. Cells from all tumors (n = 46) formed colonies in vitro. Tamoxifen (10~7,1CT6M) inhibited colony formation to 72 and 53% of control values, respectively. The inhibitory effect of tamoxifen could be reversed with the addition of estradici (10~10 to 10~8 M) to the medium. Estradiol (10~10...

1A,25-Dihydroxyvitamin D3 (1,25D3) exhibits antitumor activity in a variety of cancers including squamous cell carcinoma (SCC). Intrinsic resistance of SCC cells to cisplatin was observed and led to the investigation into whether 1,25D3 sensitizes SCC cells to cisplatin. Pretreatment with 1,25D3 followed by cisplatin enhanced growth inhibition in SCC cells compared with 1,25D3 alone as assessed...

Endothelial progenitor cells (EPCs) can be isolated from adult peripheral and umbilical cord blood and expanded exponentially ex vivo. In contrast, human umbilical vein endothelial cells (HUVECs) or human aortic endothelial cells (HAECs) derived from vessel walls are widely considered to be differentiated, mature endothelial cells (ECs). However, similar to adult- and cord blood-derived EPCs, H...