The central limit theorem (CLT) for stationary ergodic Markov chains is investigated. We give a short survey of related results on the CLT for general (not necessarily Harris recurrent) chains and formulate a new sufficient condition for its validity. Furthermore, Markov operators are considered which admit invariant orthogonal splittings of the space of square-integrable functions. We show how...

Abstract The study of the Romanian language and literature is a compulsory subject for students Hungarian minority in Romania. However, most effective learning methods paradigms take into account exploit students’ awareness linguistic repertoire. Such didactic approach builds on skills teaches children to use their resources through teaching situations embedded everyday school life that focus o...

This introduction to the special issue provides a context for the contributing articles. for readers who are not familiar with cognitive load theory (CLT), it provides a very brief description of assumptions regarding memory systems and learning processes, different types of cognitive load (intrinsic, extraneous, and germane), and design implications. Whereas traditional CLT research focused on...

BACKGROUND To evaluate the reliability of the Cogan lid twitch (CLT) test in a neuro-ophthalmology clinic. METHODS CLT testing was performed on adult patients presenting to the neuro-ophthalmology clinic by the neuro-ophthalmologist. The patients were instructed to look straight ahead, up, down, and straight ahead again. The upper eyelids were carefully evaluated immediately following this mo...

The objective of this study was to develop an efficient ocular nanovesicular carrier providing a controlled delivery of Clotrimazole (CLT); a water insoluble antifungal drug. The nanovesicular carriers were formulated using Span 60 with one of the following edge activators (EA): Tween 80 (TW80), sodium cholate (SC) or sodium deoxycholate (SDC). A 3(2) full factorial design was used to study the...

The increasing resistance of the malaria parasite Plasmodium falciparum to currently available drugs demands a continuous effort to develop new antimalarial agents. In this quest, the identification of antimalarial effects of drugs already in use for other therapies represents an attractive approach with potentially rapid clinical application. We have found that the extensively used antimycotic...

INTRODUCTION Fighter pilots' muscular strength and endurance are subjected to very high demands. Pilots' fatigued muscles are at higher risk for injuries. The purpose of this study was to compare the effects of two different training methods in reducing muscular loading during in-flight and cervical loading testing (CLT). METHODS There were 16 volunteer Finnish Air Force cadets who were divid...

Screening of a phage library for peptides that bind to clotted plasma in the presence of liquid plasma yielded two cyclic decapeptides, CGLIIQKNEC (CLT1) and CNAGESSKNC (CLT2). When injected intravenously into mice bearing various types of tumors, fluorescein-conjugated CLT peptides accumulated in a fibrillar meshwork in the extracellular compartment of the tumors, but were not detectable in ot...