www.chestjournal.org CHEST / 137 / 1 / JANUARY, 2010 185 C about the risk of bleeding in critically ill patients are common. This apprehension may stem from a sense of responsibility for bleeding following procedures or anticoagulant therapy, or perhaps the fact that hemorrhage is often visible externa lly. In addition, the clinical laboratory may raise awareness by offering tests that clinicia...

The hemostatic balance is a complex system where the delicate equilibrium is regulated by several factors, including hormones. This review summarizes current knowledge of the effects of most frequent endocrine and metabolic diseases (such as hypothyroidism, hyperthyroidism, Cushing's syndrome, GH-related pituitary dysfunctions, pituitary prolactin-producing adenomas, polycystic ovary syndrome, ...

Thrombotic microangiopathy (TMA) is a pathological lesion associated with broad range of underlying disorders. Although the kidney most frequently involved organ, kidney-limited or -predominant TMA not infrequently encountered1. In addition to common complement- and coagulation-associated gene mutations, there are still other unidentified genes in process.