objective(s): incidence of neurocognitive and psychological disorders may be related to serum homocystein (hcy), cobalamin (vitamin b12 ) and folate levels in old people. the aim of this study was to assess the relation between hcy, cobalamin, folate and neurocognitive and/or psychological disorders in the elderly.   materials and methods: in this cross-sectional study, 280 subjects with ≥ 65 y...

OBJECTIVE Transcobalamin II deficiency is one of the rare causes of inherited vitamin B12 disorders in which the patients have characteristically normal or high vitamin B12 levels related to the transport defect of vitamin B12 into the cell, ending up with intracellular cobalamin depletion and high homocysteine and methylmalonic acid levels. MATERIALS AND METHODS Herein, we describe the findi...

Pernicious anemia (also known as Biermer's disease) is an autoimmune atrophic gastritis, predominantly of the fundus, and is responsible for a deficiency in vitamin B12 (cobalamin) due to its malabsorption. Its prevalence is 0.1% in the general population and 1.9% in subjects over the age of 60 years. Pernicious anemia represents 20%-50% of the causes of vitamin B12 deficiency in adults. Given ...

AIMS To compare the efficacy of sublingual and oral administration of 500 micro g of cobalamin in subjects with cobalamin deficiency. MATERIALS AND RESULTS Thirty subjects with low serum concentrations of cobalamin participated in the study. Subjects were randomly allocated to receive one tablet daily of 500 micro g cobalamin sublingually or orally, or two tablets daily of a vitamin B complex...

In the three domains of life, vitamin B12 (cobalamin) is primarily used in methyltransferase and isomerase reactions. The methyltransferase complex MtrA-H of methanogenic archaea has a key function in energy conservation by catalysing the methyl transfer from methyl-tetrahydromethanopterin to coenzyme M and its coupling with sodium-ion translocation. The cobalamin-binding subunit MtrA is not ho...

Rhode Island Hospital, Department of Neurology, Alpert Medical School, Brown University, Providence, RI, USA Movement Disorders Program, Butler Hospital, Department of Neurology, Alpert Medical School, Brown University, Providence, RI, USA *Author for correspondence: [email protected] “Vitamin B12 (cobalamin) deficiency has long been associated with neurological impairments, particularl...

BACKGROUND Cobalamin (vitamin B12) deficiency, the most common cause of megaloblastic anemia, is treated with intramuscular (IM) cobalamin. It has been suggested by some investigators that oral (p.o.) cobalamin treatment may be as effective in the treatment of this condition, with the advantages of ease of administration and lower cost. OBJECTIVE This study assessed the effects and cost of p....

n engl j med 367;4 nejm.org july 26, 2012 385 Failures of Cobalamin Assays in Pernicious Anemia To the Editor: Cobalamin (vitamin B12) assays have been central to the diagnosis of clinical cobalamin deficiency such as pernicious anemia because the diagnostic sensitivities of older assays have been approximately 95%.1 However, the competitive-binding luminescence assay (CBLA) replaced older micr...