BACKGROUND Renal insufficiency is a risk factor for cardiovascular disease in patients with renal disease or coronary heart disease; however, it is unknown whether renal function is an independent predictor of cardiovascular disease in the general population. METHODS We investigated whether the level of renal function, estimated by glomerular filtration rate, was associated with the risk of i...

BACKGROUND Medication safety in patients with chronic kidney disease (CKD) is a growing concern. This is particularly relevant in older adults due to underlying CKD. Metformin use is contraindicated in patients with abnormal kidney function; however, many patients are potentially prescribed metformin inappropriately. We evaluated the prevalence of CKD among older adults prescribed metformin for...

INTRODUCTION Serum cystatin C can improve glomerular filtration rate (GFR) estimation over creatinine alone, but whether this translates into clinically relevant improvements in drug dosing is unclear. METHODS This prospective cohort study enrolled adults receiving scheduled intravenous vancomycin while hospitalized at the Mayo Clinic in 2012. Vancomycin dosing was based on weight, serum crea...

The purpose of this study was to determine the number of prescribed antibiotics being appropriately adjusted and to assess antibiotics with the highest incorrect dosing based on the patient’s renal function according to distinguished guidelines. The study was conducted at a 446-bed university hospital. One hundred and fifty patients admitted through different wards of the hospital were included...

Medications are an important part of the management patients with kidney disease. When used appropriately, pharmacotherapy can slow disease progression and reduce morbidity mortality. Unfortunately, reduced function significantly alter pharmacokinetics pharmacodynamics many medications, putting at risk for drug toxicity if modifications to therapy not appropriately managed. Adding complexity ap...

The Cockcroft-Gault (CG) equation has become perhaps the most popular practical approach for estimating renal function among health care professionals. Despite its widespread use, clinicians often overlook not only the limitations of the original serum creatinine (SCr) based equation, but also may not appreciate the validity of the many variations used to compensate for these limitations. For c...

Risk of nephrotoxicity in liver transplant patients on calcineurin inhibitors (CnIs) is a concern. Several controlled trials reported benefit everolimus (EVR) minimizing this risk when combined with reduced CnI dose. To systematically review the efficacy and safety EVR, alone or dose, as compared to post-liver transplantation. We searched MEDLINE, Scopus, Cochrane Library for randomized compari...