INTRODUCTION Non-steroidal anti-inflammatory drugs and corticosteroids are both used in the treatment acute gouty arthritis and may adversely interact with colchicine. Gastrointestinal toxicity of colchicine is dose-dependent and can be aggravated by drug-drug and drug-patient interactions. CASE PRESENTATION Colonic perforation associated with second-line administration of colchicine for acut...

Colchicine, both in vitro and in vivo, inhibits secretion of albumin and other plasma proteins. In vitro, secretion by rat liver slices is inhibited at 10-minus 6 M with maximal effect at 10-minus 5 M. Inhibition of secretion is accompanied by a concomitant retention of nonsecreted proteins within the slices. Colchicine does not inhibit protein synthesis at these concentrations. Vinblastine als...

Abstract: Purpose: Alzheimer’s is a disease affecting mostly the Older population leading to deterioration of cognitive capabilities. The protective effect Caffeic acid in Colchicineinduced dementia was evaluated current study. Materials and Methods: Colchicine administered intracerebroventricularly (ICV) lateral ventricle brain (at coordinates 0.8 mm posterior bregma, 1.8 sagittal suture, 3.6 ...

B-acute lymphoblastic leukemia (B-ALL) is the frequent pediatric malignity. Chemotherapy is the most practical approaches to deal with such malignancies. Microtubule-targeted agents are one of the most strategic drugs which formerly use in chemotherapy.Although,colchicine-binding anti-tubulin agents exhibited promising effects in clinical trials, their exact mechanism of action is not fully und...

Effects of subchronic administration of haloperidol on the circling behavior induced by dopamine agonists were examined in rats treated with colchicine. Methamphetamine and apomorphine produced contralateral or ipsilateral rotation in colchicine-treated rats, and these circling behaviors were significantly increased by subchronic treatment with haloperidol. These results suggest that developmen...

It is conventional to divide the management of gout into the treatment of the acute attacks, the interim treatment, and treatment of the tophaceouy stage.' It is probably fair to say that, at least until 1950, virtually everything we did in the management of patients with gout was empiric. The use of colchicine developed on a purely empiric basis and has a respectable and fascinating history; t...

The effect of the microtubule inhibitor colchicine on the metabolism of (125)I-low density lipoprotein (LDL) by cultured human skin fibroblasts and aortic medial cells was studied in vitro. Colchicine did not alter the binding of LDL to cell surface receptors. However, the rate of LDL endocytosis was reduced to 58% of that expected. Despite diminished endocytosis, LDL was found to accumulate wi...