Expression of the urokinase plasminogen activator (uPA) increases during the progression of colorectal tumors from adenomas to carcinomas. The highest amounts of uPA are found at the invasion front of carcinomas, which also displays a strong expression of nuclear -catenin and is therefore a region expressing -catenin target genes at high levels. Here we show that -catenin contributes to the tra...

Nonsteroidal anti-inflammatory drugs reduce the incidence and mor tality of colorectal carcinoma. Their chemopreventive effects appear to be due to inhibition of cyclooxygenase (COX)-2. Here, we have studied the relationship between the COX-2 mRNA levels and pathological charac teristics in 43 primary colorectal carcinomas. COX-2 levels were signifi cantly higher in tumors with larger sizes and...

BACKGROUND/OBJECTIVE Metastatic adenocarcinoma from an unknown primary site is a common clinical problem. Determining the cytokeratin (CK) 7/CK20 pattern of tumors is one of the most helpful procedures for this purpose since the CK7-/CK20+ pattern is typical of colorectal adenocarcinomas. CDX2, a critical nuclear transcription factor for intestinal development, is expressed in intestinal epithe...

Abstract Colorectal carcinomas in ulcerative colitis patients are more commonly missed endoscopically compared to those other symptomatic patients. They may present as flat lesions on a background of colitis, making them harder visualise. Those presenting after negative colonoscopies termed interval cancers, and account for up 50% colorectal cancers with inflammatory bowel disease (IBD). Profes...

Objective: Colorectal cancer is one of the leading causes of cancer death in both developed and developing nations. Cathepsin D, a member of the aspartic protease family, induced by estrogen, was proved to be closely correlated with poor prognosis in breast cancer, but its role in colorectal cancer is not well established. We aimed in this study to evaluate the immunohistochemical expression of...

A progressive accumulation of genetic alterations underlies the adenoma-carcinoma sequence of colorectal cancer. This accumulation of mutations is driven by genetic instability, of which there are different types. Microsatellite instability (MSI) is the predominant type present in the tumours of Lynch syndrome patients and in a subset of sporadic tumours. It is generally accepted that MSI can b...

adenocarcinomas. Adenosquamous carcinomas with consisting of both glandular and squamous histologic components are a rare malignancy of the colon and rectum. This tumor type was originally described by Herheimer in 1907. Subsequent reports of adenosquamous carcinomas of the rectum and/or colon are limited as the estimated incidence of adenosquamous carcinomas of the colon and rectum is approxim...

OBJECTIVE In colorectal carcinomas, tumor budding has been defined as the presence of isolated single tumor cells or small cell clusters in the stroma at the invasive tumor margin. In this study, the relationship between tumor budding density at the invasive tumor margin and pathological parameters is investigated. MATERIAL AND METHOD Haematoxylin and eosin stained slides of 73 cases with col...

PURPOSE The purpose of this study was to investigate the significance of fascin expression in colorectal carcinoma. METHODS This is a retrospective study of 167 consecutive, well-documented cases of primary colorectal adenocarcinoma for which archival material of surgical specimens from primary tumor resections were available. We chose a representative tissue sample block and examined fascin ...

Expression of the urokinase plasminogen activator (uPA) increases during the progression of colorectal tumors from adenomas to carcinomas. The highest amounts of uPA are found at the invasion front of carcinomas, which also displays a strong expression of nuclear beta-catenin and is therefore a region expressing beta-catenin target genes at high levels. Here we show that beta-catenin contribute...