Increased levels of hemostatic factors and genetic mutations of proteins involved in coagulation may play a role in the pathogenesis of coronary artery disease. We investigated clotting activity of factors II (FII:C), V (FV:C), VII (FVII:C), and X (FX:C), the prothrombin gene 20210G3A transition, and the factor V Leiden mutation in 200 survivors of myocardial infarction and in 100 healthy contr...

Increased levels of hemostatic factors and genetic mutations of proteins involved in coagulation may play a role in the pathogenesis of coronary artery disease. We investigated clotting activity of factors II (FII:C), V (FV:C), VII (FVII:C), and X (FX:C), the prothrombin gene 20210G3A transition, and the factor V Leiden mutation in 200 survivors of myocardial infarction and in 100 healthy contr...

factor v (fv) deficiency is a rare bleeding disorder (rbd) that inherit in autosomal recessive manner. diagnosis of fv deficiency (fvd) is made by routine coagulation tests, fv activity and molecular analysis. in patients with fvd, routine coagulation tests including activated partial thromboplastin time (aptt), prothrombin time (pt) and evenbleeding time (bt) are prolongedwhile thrombin time (...

To investigate the molecular mechanisms of the quantitative factor V (FV) deficiency associated with the FV R2 haplotype, 4 missense mutations, Met385Thr, His1299Arg, Met1736Val, and Asp2194Gly, identified in the R2 haplotype allele, were analyzed by in vitro expression studies. The FV variant carrying all 4 mutations showed a markedly lower steady-state expression level than wild-type FV becau...

Thrombokinase has been isolated from bovine plasma in a form that approached electrophoretic homogeneity` and gave a single boundary in the ultracentrifuge.' Such material has four separately measurable activities: 1. activation of prothrombin in the presence of oxalate; 2. activation of prothrombin in the presence of ionic calcium, phospholipid and factor V; 3. activation of chymotrypsinogen; ...