H EMOSTATIC DISORDERS with a varying incidence of bleeding, are common in the dysproteinemias, and are characteristic of the macroglobulinemia of \\Taldenstr#{246}m These abnormalities are most frequently attributed to abnormal platelet function,1 and depression of specific clotting factors appears to be a rare occurrence. Nilehn2 includes four instances of antihemophilic globulin ( factor VIII...

Previously we created two strains of factor VIII-deficient mice by insertion of a neo gene into (1) the 3' end of exon 16 and (2) exon 17 of the factor VIII gene. Affected mice of both strains have no plasma factor VIII activity, yet are healthy with no spontaneous bleeding. Factor VIII-deficient females bred with affected males survive pregnancy and delivery. We used reverse transcriptase-poly...

Introduction Cerebral venous sinus thrombosis (CVST), although a common diagnosis, is missed frequently by both general practitioners and neurologists. The most common presenting complaints are headache with focal neurological symptoms such as weakness, numbness, and aphasia. CVST has a female predominance of 3:1. A risk factor usually is able to be determined, most common of which is oral cont...

A 32-year-old primigravid woman developed acquired factor VIII inhibitor after delivery. She presented with postpartum hemorrhage and large hematoma in episiotomy site. Laboratory examinations showed markedly prolonged activated partial thromboplastin time, low levels of factor VIII (8%), and factor VIII inhibitor (2 Bethesda units). The bleeding was controlled successfully using combined treat...

We report a rare complication of factor V deficiency in a patient having Legionella pneumonia. This patient also had other complications like severe acute respiratory distress syndrome, acute kidney injury, and septic shock that required venous-venous extracorporeal membrane oxygenation support. This is the first reported case of acquired factor V deficiency in a patient receiving extracorporea...

Tests used to evaluate different aspects of hemostasis are the following: •Bleeding time: This measures the time taken for a standardized skin puncture to stop bleeding and provides an in vivo assessment of platelet response to limited vascular injury. The reference range depends on the actual method employed and varies from 2 to 9 minutes. Prolongation generally indicates a defect in platelet ...

BACKGROUND AND OBJECTIVE Activated protein C (APC)-resistance, the most common risk factor for venous thrombosis described so far, is due to a single point mutation in the factor V gene. As a result, inactivation of factor-activated factor V by APC is impaired, which leads to a hypercoagulable state and a lifelong increased risk of thrombosis. The importance of protein S as an anticoagulant pro...

A coagulation test abnormality, termed activated protein C (APC) resistance, involving poor anticoagulant response to APC is currently the most common laboratory finding among venous thrombophilic patients. Because the anticoagulant activity of APC involves inactivation of factors Va and Vllla, studies were made to assess the presence of abnormal factors V or VIII. Diluted aliquots of plasma fr...