There is increasing knowledge about considerable comorbidity between psychiatric and somatic diseases, questioning whether variations in genes could be predisposing factors for both conditions. With respect to the multiple interactions between brain and body investigations have centered on variants in several candidate genes for proteins that mediate these interactions and therefore also have i...

The association between retrospectively reported childhood conduct disorder (CD) and a history of alcohol dependence (AD) was examined in a sample of 2,682 male, female, and unlike-sex adult twin pairs. There was a strong association between CD and AD in both men (tetrachoric r = .34, odds ratio = 2.8) and women (tetrachoric r = .53, odds ratio = 9.9). Genetic factors accounted for most of the ...

The global strategic goal of reducing health care cost, especially the prospects for massive increases due to expanding markets for health care services demanded by aging populations and/or people with a wide range of chronic disorders-disabilities, is a complex and formidable challenge with many facets. Current projections predict marked increases in the demand for health driven by both the ex...

The characterization of genes responsible for glaucoma is the critical first step toward the development of gene-based diagnostic and screening tests, which could identify individuals at risk for disease before irreversible optic nerve damage occurs. Early-onset forms of glaucoma affecting children and young adults are typically inherited as Mendelian autosomal dominant or recessive traits wher...

consistent protective effect of regular use of non-steroidal anti-inflammatory drugs [6] and the important role of several pro-inflammatory cytokines during carcinogenesis [7] . Interestingly, the cyclooxygenase-2 enzyme, which is established as an effective chemoprevention target, is present predominantly in stromal cells, including macrophages, in ‘sporadic’ colorectal adenomas, reminiscent o...

Introduction: Andropause is a common clinical entity of advanced age, with a decline in androgen levels in males. Many of the signs of male aging are results of this condition with significant decline in their quality of life and adverse effects on multiple organ systems function. Androgen Deficiency of the Aging Male (ADAM) questionnaire is one of the most applied screening tools for androgen ...

Perinatal AIS The incidence of perinatal AIS, defined as occurring one month before to one month after delivery, is approximately 4 per 10 000 full-term babies.2 Direct causes for newborn stroke are not well understood. Predisposing maternal factors may include choreoamnionitis, premature rupture of membranes, and first-time pregnancy.3 The birthing process itself may be a risk, and AIS is like...

A cross sectional population based epidemiological survey of 899 adults aged between 15 and 59 was undertaken in two urban areas of demographic surveillance sites in Dar es Salaam, Tanzania, using the Clinical Interview Schedule Revised. Significantly higher rates were found among those who had experienced more than three severe life events in the last six months and relationship difficulties a...

Background: Thyroid cancer is the most common endocrine malignancy. Several risk factors were found to play a role in thyroid cancer. The purpose of the study was to determine the risk factors for thyroid cancer, in Babol, north of Iran. Method: 80 patients with thyroid cancer were selected as case group and 160 people living in the neighborhood of the patients as control group. Risk factors in...

background: alzheimer’s disease (ad) is the most common type of dementia. demonstrating the modifiable risk factors of ad can help to plan for prevention of this disease. the aim of the current review was to characterize modifiable cardiovascular risk factors of ad using existing data and determine their contribution in ad development in iran and the world. methods: the systematic search was do...