The kinetic stability of non-covalent macromolecular complexes controls many biological phenomena. Here we find that physical models of complex dissociation predict that competitor molecules will, in general, accelerate the breakdown of isolated bimolecular complexes by occluding rapid rebinding of the two binding partners. This prediction is largely independent of molecular details. We confirm...

We adapt the competitive location model based on maximal covering to include the knowledge that a competitor will enter the market later with a single new facility. The objective is to locate facilities under a budget constraint in order to maximise the remaining market share after the competitor’s later entry. We develop mixed zero-one programming formulations for each of the following three s...

Eye movements were monitored as participants followed spoken instructions to manipulate one of four objects pictured on a computer screen. Target words occurred in utterance-medial (e.g., Put the cap next to the square) or utterance-final position (e.g., Now click on the cap). Displays consisted of the target picture (e.g., a cap), a monosyllabic competitor picture (e.g., a cat), a polysyllabic...

The purpose of the current research is to examine the influence of affective dispositions and the sequencing of affective and cognitive responses to mediated entertainment. Affective dispositions are manipulated so as to match a liked competitor against one who is disliked. The results indicate that viewers’ emotional responses and assessments of satisfaction with a win or loss were dependent o...

Key predictions of unequal competitor ideal free distribution models were tested using a continuous input situation. Ten individually identi®able cichlid ®sh competed for food items at either end of their tank. Their distribution ®tted the predictions of the equal competitor, continuous input ideal free model almost perfectly. However, examination of individual intakes revealed signi®cant varia...

A comparative PCR assay, for the absolute quantitation of specific mRNAs in cell and tissue samples, has been designed to overcome problems with previous techniques. cDNAs made from the RNAs are co-amplified with "competitor" plasmid templates under conditions in which reagents are not limiting at the equivalence point, thereby preventing competition between target and competitor templates and ...