Complement pathway activation was found to occur frequently in schizophrenia, and complement 3 (C3) plays a major role in this process. Previous studies have provided evidence for the possible role of C3 in the development of schizophrenia. In this study, we hypothesized that the gene encoding C3 (C3) may confer susceptibility to schizophrenia in Han Chinese. We analyzed 7 common single nucleot...

several representations of the generalized drazin inverse of an anti-triangular block matrix in banach algebra are given in terms of the generalized banachiewicz--schur form.

background: determination of reference ranges of each serum protein in normal population of each country is required for studies and clinical interpretation. the aim of this study was defining reference range values of immunoglobulins and complement components in iranian healthy children. methods: this study was conducted from june 2003 to june 2006 in immunology, asthma and allergy research in...

Complement activation on human platelets is known to cause platelet degranulation and activation. To evaluate how normal platelets escape complement attack in vivo, we studied the fate of murine platelets deficient in 2 membrane complement regulatory proteins using an adoptive transfer model. We show here that deficiency of either decay-accelerating factor (DAF) or complement receptor 1-related...

The complement system has been thought to originate exclusively in the deuterostomes. Here, we show that the central complement components already existed in the primitive protostome lineage. A functional homolog of vertebrate complement 3, CrC3, has been isolated from a 'living fossil', the horseshoe crab (Carcinoscorpius rotundicauda). CrC3 resembles human C3 and shows closest homology to C3 ...

Given a subset W of an abelian group G, C is called additive complement for if W+C=G; if, moreover, no proper has this property, then we say that minimal W. It natural to ask which subsets can arise as complements some We show in finite every non-empty size |C|≤22/3|G|1/3/((3elog⁡|G|)2/3 As corollary, deduce infinite complement. also derive several analogous results “dual” problems about maxima...

A renewed interest in the role of complement in the pathogenesis of glomerular diseases has improved our understanding of their basic, underlying physiology. All 3 complement pathways-classical, lectin, and alternative-have been implicated in glomerular lesions both rare (e.g., dense deposit disease) and common (e.g., IgA nephropathy). Here we review the basic function of these pathways and hig...

We molecularly dissected leptomeningeal metastasis, or spread of cancer to the cerebrospinal fluid (CSF), which is a frequent and fatal condition mediated by unknown mechanisms. We selected lung and breast cancer cell lines for the ability to infiltrate and grow in CSF, a remarkably acellular, mitogen-poor metastasis microenvironment. Complement component 3 (C3) was upregulated in four leptomen...