The Structural T-cell Receptor Database (STCRDab; http://opig.stats.ox.ac.uk/webapps/stcrdab) is an online resource that automatically collects and curates TCR structural data from the Protein Data Bank. For each entry, the database provides annotations, such as the α/β or γ/δ chain pairings, major histocompatibility complex details, and where available, antigen binding affinities. In addition,...

Although tribimaximal mixing (TBM) and quark-lepton complementarity (QLC) are both compatible with experimental data within one standard deviation (1σ), the TBM and QLC assumptions are mutually exclusive by 56σ. [email protected] [email protected] Two popular assumptions in particle phenomenology model building are tribimaximal mixing (TBM) and quark-lepton complementarity(QLC). In t...

As pointed out by many authors, recent observations are consistent with an intriguing relation between the Cabibbo angle θC and the solar neutrino mixing angle θ12, namely θ12 ≃ π/4 − θC. Such quark-lepton complementarity (QLC) may be a signal of an underlying quark-lepton unification at short distances. We discuss possible ways to realize this relation in realistic quark-lepton unification the...

We consider a scenario for the Quark-Lepton Complementarity (QLC) relations between mixing angles in which the bi-maximal mixing follows from the neutrino mass matrix. According to this scenario in the lowest order the angle θ12 is ∼ 1σ (1.5− 2 ◦) above the best fit point coinciding practically with the tri-bimaximal prediction. Realization of this scenario in the context of the seesaw type-I m...

The Complementarity Determining Regions (CDRs) of antibodies are assumed to account for the antigen recognition and binding and thus to contain also the antigen binding site. CDRs are typically discerned by searching for regions that are most different, in sequence or in structure, between different antibodies. Here, we show that ~20% of the antibody residues that actually bind the antigen fall...

A large body of data exists demonstrating the key role of FcRn in extending the half-life of therapeutic antibodies by rescuing them from lysosomal degradation. This led to the widely accepted hypothesis that FcRn binding of an IgG via the CH2-CH3 interface of Fc correlates with IgG half-life. Several studies have demonstrated that in vivo half-life can be modified by changing the binding affin...

Recently, J.-S. Chen and P. Tseng extended two merit functions for the nonlinear complementarity problem (NCP) and the semidefinite complementarity problem (SDCP) to the second-order cone commplementarity problem (SOCCP) and showed several favorable properties. In this paper, we extend a merit function for the NCP studied by Yamada, Yamashita, and Fukushima to the SOCCP and show that the SOCCP ...

We have studied the allelic diversity and de novo mutations at the hypervariable minisatellite locus D7S22. A four-state minisatellite variant repeat unit mapping by PCR (MVR-PCR) method was developed for this purpose, and a substitution polymorphism close to the repeat array was used to design allele-specific flanking primers to study individual haplotypes in genomic DNA. A total of 150 allele...

In order to address the mechanism of enhancement of the affinity of an antibody toward an antigen from a thermodynamic viewpoint, anti-hen lysozyme (HEL) antibody HyHEL-10, which also recognize the mutated antigen turkey lysozyme (TEL) with reduced affinity, was examined. Grafting high affinity toward TEL onto HyHEL-10 was performed by saturation mutagenesis into four residues (Tyr(53), Ser(54)...

We have explored the structural basis of idiotopes associated with the major idiotype (CRIA) of A/J anti-p-azobenzenearsonate antibodies, with emphasis on the regions of contact with anti-idiotypic antibody. The analysis was facilitated by a recent description of the three-demensional structure of the Fab portion of a CRIA-related antibody molecule. Direct binding measurements failed to reveal ...