leishmaniasis is one of the major health problems and categorized as a class i disease (emerging and uncontrolled) by world health organization (who), causing highly significant morbidity and mortality. indeed, more than 350 million individuals are at risk of leishmania infection, and about 1.6 million new cases occur causing more than 50 thousands death annually. because of the severe toxicity...

In order to prepare pure enzyme before gene cloning the proteins were separated by fast protein liquid chromatography and used to prepare monoclonal antibodies to papaya proteinase A and B. Crude spray-dried latex from Powell and Scholefield was dialysed against 1,3-diaminopropane and the enzyme isolated by the method of Goodenough & Owen (1986) using 6 mM-diaminopropane as buffer and a gradien...

Eysenhardtia polystachya is widely used in folk medicine as an anti-rheumatic and analgesicagent, but no systematic study of its effects on several markers associated with rheumatoidarthritis and its ethnomedical use as analgesic agent has been performed. We evaluated theanti-arthritic and antinociceptive properties of an ethanolic extract of E. polystachya (EE) barkand its rich-flavonoids frac...

Tato případovĂĄ studie přibliĹžuje dramatickĂŠ ĹživotnĂ­ osudy sourozencĹŻ Gerty (Gertrudy) a Harryho (Heřmana) FreundovĂ˝ch v kontextu mezivĂĄlečnĂŠho komunistickĂŠho hnutĂ­. Narodili se v roce 1908 (Harry) 1909 (Gerta) do praĹžskĂŠ středostavovskĂŠ, nĂĄrodnostně smĂ­ĹĄenĂŠ rodiny (s německou, Ĺžidovskou českou identitou) oba byli pod vlivem matky Terezie FreundovĂŠ (1885–1982...

PURPOSE We conducted a retrospective analysis to determine if adjuvant chemotherapy prolongs overall survival in patients with pathologic stage IB lung adenocarcinoma who had undergone complete resection and were defined as high-risk by a newly developed recurrence risk scoring model. MATERIALS AND METHODS Patients who underwent curative resection for stage IB lung adenocarcinoma were analyze...

OBJECTIVE The aim of this study was to evaluate the prognostic value of serum CA-125 in advanced epithelial ovarian cancer with complete remission after primary adjuvant chemotherapy. METHODS We reviewed the records of 120 patients with advanced epithelial ovarian cancer who underwent primary surgery followed by adjuvant therapy at our institution between January 1998 and December 2005. RES...

Peptide vaccines using specific antigens with poor immunogenicity like GnRH-I are unable to develop an effective adaptive immune response and require the presence of adjuvants, essential to lymphocytic activation. Three chitosan formulations were evaluated for their ability as adjuvant of a poor immunogenic peptide vaccine against GnRH-I. Male Sprague-Dawley rats were immunized subcutaneously w...