Chemotherapy, in conjunction with other methods of treatment, was used in 100 patients with invasive hydatidiform mole or choriocarcinoma following mole. When treatment was instituted within two to six months of the antecedent mole serious drug resistance was not encountered, drug toxicity was slight, the duration of treatment was comparatively short, and sustained remissions were obtained in 5...

OBJECTIVE A twin pregnancy consisting of a complete hydatidiform mole with a coexisting normal fetus is extremely rare with an incidence of 1/22,000 to 1/100,000. The incidence of preterm delivery is high and few pregnancies reach near term with a viable fetus. CASE REPORT A 34-year-old woman presented at 20 weeks of gestation with increased levels of serum beta human chorionic gonadotropin (...

J. E. Carvell, MB, ChB. MMedSc, FRCS, Senior Registrar Nuflield Department ofOrthopaedic Surgery, Nuffield Orthopaedic Centre, Headington, Oxford 0X3 7LD, England. Professor R. A. Dickson, MA, ChM, FRCS Department ofOrthopaedic Surgery, Clinical Sciences Building, St. James’s University Hospital, Leeds LS9 7TF, England. Requests for reprints should be sent to Professor R. A. Dickson. © 1982 Bri...

OBJECTIVE To define the concentrations of inhibin in serum and tissue of patients with hydatidiform mole and assess their value as a clinical marker of the condition. DESIGN Prospective study of new patients with hydatidiform mole, comparison of paired observations, and case-control analysis. SETTING A university hospital, two large public hospitals, and a private women's clinic in Japan. ...

Background: The pathomechanisms of gestational trophoblastic disease have not yet been able to be extensively understood. It is associated with oxidative damage related to the production of reactive oxygen species (ROS). Estrogen, as well as all of its metabolites, can produce ROS. Therefore it is necessary to analyze how far the involvement of estrogen, in this case 17β estradiol, to the patho...

Hydatidiform mole (often referred to as molar pregnancy) is the most common disorder in a category of pathologies known as Gestational Trophoblastic Diseases that are associated with abnormal fertilization in pregnancy. Current practices in screening and monitoring during early pregnancy allow for better identification of hydatidiform mole, sometimes prior to the onset of significant symptoms.O...

Protein degradation by the ubiquitin-proteasome system is central to cell homeostasis and survival. Defects in this process are associated with diseases such as cancer and neurodegenerative disorders. The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a bar...

Six cases of hydatidiform mole associated with normal chorionic villi and a normal embryo/fetus (in five cases) were investigated with interphase cytogenetic and DNA cytometric analyses for diagnostic purposes. DNA probes specific for the pericentromeric regions of chromosomes 1 and X and for the long arm of chromosome Y were used. In four cases a dizygotic twin pregnancy could be proven. In th...

BACKGROUND Hydatidiform mole is an important obstetric problem which can result in harmful and serious outcomes. In this study, an attempt was made to determine the proportion of hydatidiform mole in prenatal clinics of Iran University of Medical Sciences (IUMS) to find the precise frequency of this disease. METHODS Between January 2012 and January 2013, all women who immediately after positi...

BACKGROUND Gestational Trophoblastic Disease (GTD) is a heterogeneous group of diseases that includes partial and complete hydatidiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumour. The incidence of GTD varies in different parts of the world. The malignant potential of this disease is higher in South East Asia in comparison to western countries. Objectives of stu...