background: topical anesthesia has been widely advocated as an important component of atraumatic administration of intraoral local anesthesia. the aim of this study was to use direct observation of children’s behavioral pain reactions during local anesthetic injection using cotton-roll vibration method compared with routine topical anesthesia. materials and methods: forty-eight children partici...

One of the important Multi-component reaction (MCRs) is the synthesis of dihydropyrano chromene derivatives by one-pot reaction. In this research, an inexpensive and effective one pot three component procedure with good yields for the synthesis of dihydro pyrano chromenes is reported. In this method, the synthesis of pyrano chromene derivatives was followed by using 4-hydroxycoumarin, malononit...

The abilities of normal mouse peritoneal exudate cells and fluids to mediate in vitro cell adherence reactions to Ascaris suum juveniles were investigated. Exudates were induced by intraperitoneal injection of Sephadex G-25 or by infection with A. suum and changes in the peritoneal cell populations were determined. The presence of a heat-labile component, probably complement, and a heat-stable ...

an efficient, one-pot, four-component procedure for the synthesis of a small library of new chiral spiro- oxindolopyrrolidines with high regio-, diastereo- (>99:1 dr), and enantioselectivity (up to 80% ee) is described. in this process, the regio- and stereochemical 1,3-dipolar cycloaddition of azomethine ylides, which were generated insitu by the reaction of isatin derivatives and sarcosin,wit...

let $pounds$ be the category of locally compact abelian groups and $a,cin pounds$. in this paper, we define component extensions of $a$ by $c$ and show that the set of all component extensions of $a$ by $c$ forms a subgroup of $ext(c,a)$ whenever $a$ is a connected group. we establish conditions under which the component extensions split and determine lca groups which are component projective. ...

Efficient bismuthand iron-catalyzed three-component syntheses of α-arylglycines have been developed. These methods provide a general, atom-economic route to various N-protected α-arylglycines starting from readily available amides (or carbamates), glyoxalates, and (hetero)arenes with water as the only by-product. Scope and limitations of bismuthand iron-catalyzed reactions are discussed and com...

[bmim][OTf] can promote regio- and chemo-selective glycosylation reactions at room temperature. Furthermore, the applicability to ambient three-component reactivity-based one-pot glycosylation reactions is demonstrated for the synthesis of several trisaccharides.

Four-component reactions between amino alcohols, aldehydes, isocyanides and thiols proceed rapidly under microwave or conventional heating at 60 ◦C in methanol. The reaction is successful with a wide range of components and gives access to potentially drug-like products containing amine, amide and thioether functionality in moderate to excellent yield. The reaction conditions are also applicabl...

The full scope and limitations of solution and solid phase one-pot three component Nacyliminium ion reactions are detailed. After studying the scope in solution with respect to the carbamate, nucleophile and aldehyde component, a ‘translation’ was made to the solid phase. The solid phase reactions were eventually carried out using the so-called SEC linker system, which was previously developed ...

Four-component reactions between amino alcohols, aldehydes, isocyanides and thiols proceed rapidly under microwave or conventional heating at 60 °C in methanol. The reaction is successful with a wide range of components and gives access to potentially drug-like products containing amine, amide and thioether functionality in moderate to excellent yield. The reaction conditions are also applicabl...