Cell migration determines the complete development of mammalian tissue and other pathological phenomena. To investigate effect chemical stimuli on such behavior, cells are triggered to translate by concentration gradient different molecules 2D substrates in vitro. But date unfortunately polymeric scaffolds for cell 3D environment with have not been proposed developed yet. Herein, a novel compos...

Understanding the formation of biominerals like nacre can lead to the fabrication of more advanced biomimetic materials. Several factors are known to influence the final form of both native nacre and biomimetic synthetic variants. Two important components in calcium carbonate biominerals such as nacre are the organic scaffold and the acidic proteins. Interactions between these two components ma...

Tricalcium phosphate (TCP) and platelet-rich plasma (PRP) are commonly used in bone tissue engineering. The aim of the present study was to investigate a composite that combined TCP with PRP and assess its effectiveness in the treatment of bone defects. Cavity-shaped bone defects were established on the tibiae of 27 beagle dogs, and were repaired by pure β-TCP with bone marrow stromal cells (BM...

We here present the first successful report on combining nanostructured silk and poly(ε-caprolactone) (PCL) with a ceramic scaffold to produce a composite scaffold that is highly porous (porosity ∼85%, pore size ∼500 μm, ∼100% interconnectivity), strong and non-brittle with a surface that resembles extracellular matrix (ECM). The ECM-like surface was developed by self-assembly of nanofibrous st...

Novel scaffolds composed of poly(L-lactic acid) (PLLA) skeleton covered with bonelike apatite or apatite/collagen composite were produced via a combined phase-separation technique and an accelerated biomimetic coating process. Saos-2 osteoblast-like cells were used to evaluate the cellular behaviors on these biomimetic coatings. Cell morphologies on the surfaces of PLLA scaffolds, PLLA scaffold...

Hu Z, Zhu J, Cao X, Chan C, Li S, Guo D et al. Composite skin grafting with human acellular dermal matrix scaffold for treatment of diabetic foot ulcers: a randomized controlled trial. J Am Coll Surg 2016; 222: 1171–1179. The rates of wound healing were similar, as were rates of complications in this study that included 52 patients. Recurrent ulceration was less common in the group who had skin...

Introduction Osteo-chondral articular defects still represent a key concern in modern orthopaedic surgery and several techniques have been so far proposed (1). A novel strategy able to promote cartilage and sub-chondral bone regeneration of full-thickness defects was recently developed, consisting on implantation of a three-layered nano-composite biomimetic scaffold. This peculiar structure mim...

Tissue engineering scaffolds are highly engineered structures that accommodate cells, facilitate their expression, and resorb to facilitate regeneration of tissue. A new technique for producing controlled pore shape and pore size interconnectivity offers promise for application as a tissue engineering scaffold. Salt particles were spheroidized in a flame and sintered to provide an interconnecti...