The transdermal therapeutic systems (TTS) usually achieve constant plasma concentration for an extended period of time. This is because a sufficient drug stored in the device can keep the constant concentration on the surface of the stratum corneum during the system application. When the drug molecules are not enough to provide the constant surface concentration, the rate of drug penetration de...

Purpose: The objective of this study was to prepare Propranolol Hydrochloride controlled release matrix tablets and to investigate the effect of the polymer blends and the polymer concentration on drug release. Method: Propranolol Hydrochloride controlled release matrix tablets were prepared by direct compression technique. Hydroxypropylmethylcellulose K15M (HPMC K15M) and Carbopol 934P were us...

The initial mesh is constructed by using the concentration contours of the 2-D as implanted profile. Mesh spacing is chosen after making some 'a priori' estimates of the maximum diffusion which can occur during the specific anneal. As the source/drain profile evolves in time new mesh points are introduced by comparing the concentration ratio of adjacent nodes. This is an appropriate parameter a...