In the transient receptor potential (trp) mutant of Drosophila, the receptor potential appears almost normal in response to a flash but quickly decays to baseline during prolonged illumination. Photometric and early receptor potential measurements of the pigment suggest that the pigment is normal and that the decay of the trp response during illumination does not arise from a reduction in the a...

BACKGROUND Frusemide can inhibit various indirectly acting bronchoconstrictor stimuli in asthmatic patients. Both frusemide and bumetanide also modulate airway neurotransmission in some species but there are no data on the effect of loop diuretics on neurotransmission in man. An in vitro study was performed in human airways to investigate the possible neuromodulatory action of two loop diuretic...

The value of determining the slope of the histamine dose-response curve, in addition to the histamine provocation concentration producing a 20% reduction in FEV1 (PC20-FEV1), was assessed by analysis of histamine dose-response curves in 40 patients selected as having a wide range of increased non-specific bronchial responsiveness to inhaled histamine. The histamine dose-response curves were fou...

Studies comparing the efficacy of epidural analgesia for labour have been limited by lack of knowledge about the relative potencies of the involved agents, whether alone or in combination. Recently a clinical model to determine the minimum local analgesic concentration has been developed [1]. This study design estimated the minimum local analgesic concentration or median effective concentration...

the present study was conducted in the rangeland of glandrood watershed in the province of mazandaran. the objective of this study was to compare between the ecological amplitude of festuca ovina l., and poa bulbosa l., using the function hof along the gradient of the environmental variables. for this purpose 150 plots of 1m2 were established along the altitude gradient. the sampling method was...

The patch-clamp technique was used to study whole cell currents evoked by gamma-aminobutyric acid (GABA) in rat cerebellar granule cells cultured in 5 mM potassium, a condition that favors the development of functional GABAergic synapses. GABA activated both high- and low-sensitivity receptors. The high-sensitivity receptor had an effective concentration producing half the maximum response (EC5...

Sequential design methods for binary response variables exist for determination of the concentration or dose associated with the 50% point along the dose-response curve; the up-and-down method of Dixon and Mood is now commonly used in anesthesia research. There have been important developments in statistical methods that (1) allow the design of experiments for the measurement of the response at...

Typically, pharmacokinetic-pharmacodynamic (PK/PD) models use plasma concentration as the input that drives the PD model. However, interindividual variability in uptake transporter activity can lead to variable drug concentrations in plasma without discernible impact on the effect site organ concentration. A physiologically based PK/PD model for rosuvastatin was developed that linked the predic...

Sarday, M ay 6, 2017 persists until the infection is cleared by antibiotic therapy and/or surgical management. While the acute phase response is essential for tissue healing and regeneration, over-activation of the acute phase response is maladaptive and may lead to systemic complications including thrombosis, organ failure, and disseminated intravascular coagulation. In the setting of severe i...