Diagnosis of pigmented lesions of the oral cavity and perioral tissues is challenging. Even though epidemiology may be of some help in orientating the clinician and even though some lesions may confidently be diagnosed on clinical grounds alone, the definitive diagnosis usually requires histopathologic evaluation. Oral pigmentation can be physiological or pathological, and exogenous or endogeno...

In this article, we give an update on recent findings regarding molecular pathology in cutaneous melanocytic tumors. The focus lies on use of genetics in the diagnosis of distinct subtypes of spitzoid tumors that are often characterized by specific phenotypic-genotypic alterations that can frequently be recognized by adequate histological examination. Typical illustrating cases are given in ord...

Figure 3 Atypical acquired melanosis, shown by clusters ofabnormal melanocytes in the epithelium, migrating awayfrom the basement membrane. Squamous metaplasia ofthe epithelium, with loss ofgoblet cells, is also seen. Haematoxylin and eosin. Magnifcation x300. We present an unusual case in which conjunctival melanoma was preceded by excision of a lentigo maligna melanoma ofthe ipsilateral lower...

Diffuse cutaneous hyperpigmentation may have various causes: endocrine, metabolic, autoimmune, melanosis secondary to metastatic melanoma, drug or heavy metal poisoning. A cause to remember is acanthosis nigricans, which, in the form of paraneoplastic syndrome may be the first or even the only clinical manifestation of a cancer. The most common cause of malignant acanthosis nigricans is the gas...

We describe imaging findings in a 2-year-old girl with neurocutaneous melanosis and malignant cerebral melanoma. Because the cerebral melanoma in this child was of the amelanotic type, high-signal intensity on unenhanced T1-weighted images was not present. The cutaneous lesions played a crucial role in establishing a correct (presumed) histopathologic diagnosis on the basis of the imaging findi...

BACKGROUND Neurocutaneous melanosis (NCM) is a rare neurocutaneous syndrome characterized by the presence of multiple congenital melanocytic nevi (CMN) and the proliferation of melanocytes in the central nervous system, usually involving the leptomeninges. Chronic partial epilepsy as a sole manifestation is rare in NCM. CASE REPORT A 32-year-old man suffering from chronic partial epilepsy pre...

Effect of different concentrations hypotaurine (HTU) on melanosis and quality shrimps during 10 d storage in ice were studied. During refrigeration, the total plate count volatile basic nitrogen treated with 20 g/L HTU lowest, hardness microstructure best. Moreover, score melanoses, pH bile acid also low. Sensory evaluation showed that treatment could make shelf life 3-4 days longer compared co...

Gastrointestinal stromal tumors (GIST) are the most common mesenchymatous neoplasms of the human digestive tract. They locate preferentially in stomach, duodenum or small bowel. Usually sporadic, familial cases unrelated to neurofibromatosis may be due to germline mutations in KIT or PDGFRA. We describe the first Argentine family with GIST in which we found, diffuse cutaneous melanosis, lentigi...

Neurocutaneous melanosis (NCM) is a rare congenital syndrome consisting of benign or malignant melanotic tumors of the central nervous system with large or numerous cutaneous melanocytic nevi. The Dandy-Walker complex (DWC) is characterized by an enlarged posterior fossa with high insertion of the tentorium, hypoplasia or aplasia of the cerebellar vermis, and cystic dilatation of the fourth ven...

background although, melasma is most prevalent among asian young women, and also darkly pigmented individuals are particularly prone to developing post inflammatory hyperpigmentation, to the best of our knowledge, there are rare or no studies about the association of melasma and post inflammatory hyperpigmentation. results we found out that 24.1% of patients without melasma had post-acne pigmen...