An infant with chronic cytomegalovirus hepatitis and a child with atypical Alagille's syndrome had vitamin D deficiency rickets due to malabsorption. Both received ultraviolet irradiation. This treatment corrected biochemical abnormalities and healed the rickets. In the infant use of a sunlamp at home maintained normal 25 hydroxy-vitamin D for over a year. Our study shows that ultraviolet irrad...

background: metabolic bone diseases (mbd), including rickets and osteopenia, are important neonatal complications among preterm infants. this study aimed to determine the prevalence and risk factors of mbd in neonates with very low birth weight (vlbw). methods: this prospective study was conducted on vlbw infants from january 2012 to july 2013. inclusion criteria were birth weight of ≤1500 g an...

Abstract Rickets, a growth plate disorder, is classified into calcipenic and phosphopenic types based on the etiology. Phosphopenic rickets can be further fibroblast factor 23 (FGF23) mediated non-FGF23 mediated. FGF-23 has phosphaturic effect which results in hypophosphatemia and, therefore, accumulation of hypertrophied chondrocytes, leading to rachitic changes bones. One most common causes i...

This study was aimed to determine prevalence of vitamin D deficiency and rickets in children with cholestatic liver diseases. Forty eight children with established cholestatic liver disease who referred to gastrointestinal clinic of Children Medical Center (Tehran, Iran) between April 2010 and March 2011 were enrolled in a cross-sectional study. Laboratory analysis including calcium, phosphate,...

Rickets caused by deficiency of vitamin D has almost disappeared in Great Britain, and for this reason attention is being focused more and more on the group of conditions which in the past has been loosely termed ‘ ‘ resistant ‘ ‘ and ‘ ‘ renal ‘ ‘ rickets. Dent (1952) clarified the confusion that has surrounded the subject. He classified the etiolog ’ of the various rachitic and osteomalacic c...

Definite research for the causative factors in the nutritional disturbance known as rickets was begun by various observations as to its distribution and occurrence. In 1890 T. A. Palm (1) showed by a geographical survey that lack of sunlight seemed to be one of the chief factors in the causation of rickets. This led to the use of the sun bath in the treatment of rachitic children. In 1914 Rolli...

Rud syndrome consists of mental retardation, epilepsy, ictihyosis, dentition and skeleton defect. We report a case of Rud syndrome that have clinical, radiological and biochemical characteristics of rickets. Alteration in epidermal cholestrol metabolism, limited sun exposure or associated defects may explain this condition. All such patients need life – long rickets prophylaxis with vitamin D s...

Adult insects achieve their final form shortly after adult eclosion by the combined effects of specialized behaviors that generate increased blood pressure, which causes cuticular expansion, and hormones, which plasticize and then tan the cuticle. We examined the molecular mechanisms contributing to these processes in Drosophila by analyzing mutants for the rickets gene. These flies fail to ini...

We studied the immune system, especially the chemotactic activity of neutrophils, in ten patients with vitamin D-deficient rickets and compared the results with ten healthy controls of matched age. Among all immune system factors, the chemotactic studies persistantly showed remarkable deficiency in leukocyte mobility, both random motion and migration. When compared with controls, the findi...