introduction: an effective vaccine against hcv infection is not available. the non-structural protein 3 (ns3) of the virus as an important immunogenic candidate has been utilized in various modules. nanostructured polymers have been recently used for efficient vaccine and drug delivery. the aim of the current study was the synthesis of rns3-g2 conjugate and preliminary evaluation of its immunog...

We study the mechanism of proton transfer (PT) between the photoacid 8-hydroxy-1,3, 6-pyrenetrisulfonic acid (HPTS) and the base chloroacetate in aqueous solution. We investigate both proton and deuteron transfer reactions in solutions with base concentrations ranging from 0.25 M to 4 M. Using femtosecond midinfrared spectroscopy, we probe the vibrational responses of HPTS, its conjugate photob...

Mechanisms of DNA oxidation by copper complexes of 3-Clip-Phen and its conjugate with a distamycin analogue, in the presence of a reductant and air, were studied. Characterisation of the production of 5-methylenefuranone (5-MF) and furfural, associated with the release of nucleobases, indicated that these copper complexes oxidised the C1' and C5' positions of 2-deoxyribose, respectively, which ...

In this paper, we present a new approach for solving absolute value equation (AVE) whichuse Levenberg-Marquardt method with conjugate subgradient structure. In conjugate subgradientmethods the new direction obtain by combining steepest descent direction and the previous di-rection which may not lead to good numerical results. Therefore, we replace the steepest descentdir...

In this study it has been tried, to compare results and convergence rate of sensitivity analysis and conjugate gradient algorithms to reduce fuel consumption and increasing engine performance by optimizing the timing of opening and closing valves in XU7/L3 engine. In this study, considering the strength and accuracy of simulation GT-POWER software in researches on the internal combustion engine...

We demonstrate that two supersoluble complements of an abelian base in a finite split extension are conjugate if and only if, for each prime $p$, Sylow $p$-subgroup one complement is to the other. As corollary, we find any subgroup $N$ $G$ there exists $S$ such $S\cap N$ $G$. In particular, restricting groups allows us ease D. G. Higman's stipulation be within $S$. then consider group actions o...

Gas-phase infrared multiple photon dissociation (IRMPD) spectra have been recorded for the conjugate bases of a series of amino acids (Asp, Cys, Glu, Phe, Ser, Trp, Tyr). The spectra are dominated by strong symmetric and antisymmetric carboxylate stretching modes around 1300 and 1600 cm(-1), respectively. Comparison of the experimental spectra with spectra calculated at the DFT level suggests a...

Several lines of investigation suggest that the nondegradable fluorophores that accumulate as lipofuscin in retinal pigment epithelium (RPE) cells contribute to the etiology of macular degeneration. Despite evidence that much of this fluorescent material may originate as inadvertent products of the retinoid cycle, the enzymatic pathway by which the 11-cis-retinal chromophore of rhodopsin is gen...