Extra nodal marginal zone B-cell lymphoma (EMZL) of the conjunctiva typically arises in the marginal zone of mucosa-associated lymphoid tissue. The pathogenesis of conjunctival EMZL remains unknown. We describe an unusual case of EMZL arising from reactive lymphoid hyperplasia (RLH) of the conjunctiva. A 35-year-old woman had fleshy salmon-pink conjunctival tumors in both eyes, oculus uterque (...

BACKGROUND Lichen planus is a common inflammatory autoimmune condition of unknown etiology that commonly affects the skin and mucous membranes. Isolated ocular lichen planus is an extremely rare presentation that most commonly involves the eyelids, conjunctiva, and cornea, leading to severe scarring, and is clinically indistinguishable from other causes of cicatricial conjunctivitis. OBSERVAT...

purpose: to present a case of autosomal dominant dystrophic epidermolysis bullosa with symble-pharon formation due to eye rubbing. case report: a 10-year-old girl suffering from blistering and ulcerative lesions of the trunk and palms and dystrophic nails since childhood was referred to our clinic with a symblepharon connecting the medial portion of the right upper lid to the upper nasal quadra...

1. Seregard S. Conjunctival melanoma. Surv Ophthalmol. 1998;42:321-350. 2. McDonnell JM, Carpenter JD, Jacobs P, Wan WL, Gilmore JE. Conjunctival melanocytic lesions in children. Ophthalmology. 1989;96: 986-993. 3. Croxatto JO, Iribarren G. Malignant melanoma of the conjunctiva: report of a case. Ophthalmology. 1987;94:1281-1285. 4. Shields CL, Fassiuden A, Mashayekhi A, Shields JA. Conjunctiva...

GM1 gangliosidosis is characterized by a deficiency in the lysosomal hydrolase beta-galactosidase, progressive nervous system disease and ocular lesions. Diagnosis of GM1 gangliosidosis in humans and cats with the analogous disease has been made by measurement of the enzyme activity in various tissues including brain, liver and cultured skin fibroblasts. The authors report the use of cultured c...

OBJECTIVE To estimate the prevalence and pattern of conjuctival squamous cell carcinoma (CSCC) in patients with HIV infection. DESIGN A hospital based cross sectional study. SETTING Kenyatta National Hospital (KNH) and Kikuyu Eye Unit (KEU) during the period November 2003 and May 2004. SUBJECTS Four hundred and nine HIV positive patients. RESULTS Four hundred and nine HIV positive patie...

AIM To retrospectively study 26 patients with squamous cell carcinoma (SCC) of the ocular surface to determine pathological and clinical characteristics of tumour associated with outcome. METHODS Patients with conjunctival SCC from St Vincent's Hospital and the private ophthalmology practices of the authors were reviewed. RESULTS Patents were usually male (77%), elderly (69% > 60 years of a...

PURPOSE The purpose of this study is to test the hypothesis that a subset of conjunctival melanocytic proliferations exists that cannot be reproducibly classified as benign, malignant, or indeterminate. METHODS Three groups of excisional biopsy specimens of conjunctival melanocytic proliferations were evaluated by 5 ophthalmic pathologists. These groups included lesions that were considered b...

A first aim of the project is to determine the role of c-KIT gene amplification in uveal melanocytic lesions. Since there is a targeted designed treatment directed against c-KIT (by STI571 or Imatinib), this part of the study can have important therapeutic implications for uveal melanocytic lesions. The second part of the study uses 4 FISH probes that have been proven to be of diagnostic value ...