OBJECTIVE To evaluate the dipeptidyl peptidase-4 (DPP-4) inhibitor alogliptin in drug-naïve patients with inadequately controlled type 2 diabetes. RESEARCH DESIGN AND METHODS This double-blind, placebo-controlled, multicenter study included 329 patients with poorly controlled diabetes randomized to once-daily treatment with 12.5 mg alogliptin (n = 133), 25 mg alogliptin (n = 131), or placebo ...

OBJECTIVES To evaluate the effect of pioglitazone in people with insulin resistance, pre-diabetes and type 2 diabetes. DESIGN AND SETTING Systematic review and meta-analysis of randomised, controlled trials. DATA SOURCES Literature searches were performed across PubMed, EMBASE, MEDLINE and Cochrane Central Register of Controlled Trials from 1966 to May 2016 to identify randomised, controlle...

BACKGROUND American Indians/Alaska Natives have a greater increased risk for diabetes than non-Hispanic whites. Lifestyle interventions are effective in preventing and treating diabetes, and an interprofessional approach is important in diabetes management. COMMUNITY CONTEXT The Penobscot Nation has a health center with a wide range of services. Our goal with the Nation was to 1) establish an...

BACKGROUND Although a variety of treatment guidelines for Type 2 diabetes patients are available, a majority of patients does not achieve recommended targets. We aimed to characterise Type 2 diabetes patients from Swiss primary care who miss HbA1c treatment goals and to reveal factors associated with the poorly controlled HbA1c level. METHODS Cross-sectional study nested within the cluster ra...

background and aims. the aim of this study was to establish a relationship between salivary glucose levels and candida carriage rate in type 2 diabetes mellitus patients and assess the growth characteristics and acid production of candida in glucose-supplemented saliva. materials and methods. a total of 90 subjects, 30 with controlled type 2 diabetes, 30 with uncontrolled type 2 diabetes and 30...

background: sleep is an important aspect of healthy lifestyle. one of the prevalent diabetes mellitus-related non-vascular complications is sleep problems. the aim of this study was to investigate the effects of a non-pharmacological care plan designed based on the continuous care model (ccm) on sleep quality in patients with type ii diabetes with two month follow up. methods: this randomized c...

conclusions this study showed that audio-visual training can have a significant effect on the self-efficacy of people with type 1 diabetes. providing audio-visual equipment to referral centers of type 1 diabetics, such as hospitals, health centers, and clinics, as well as informing related officials, can be of benefit to managers. results the mean of the self-efficacy score improved significant...

New JP, Mason JM, Freemantle N, et al. Specialist nurse-led intervention to treat and control hypertension and hyperlipidemia in diabetes (SPLINT): a randomized controlled trial. Diabetes Care 2003;26:2250–5. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...