As drug delivery systems Nanoparticulan widely investigated because of many advantages such as smaller size,controlled drug release potentiaL targeting ability, enhancement of therapeutic efficacy and reduction oftoxicity. So, carbon nanotubes have recently received considerable attention as alternative drug delivery carrierIn this study we investigate interaction of tamoxifen with open-end of ...

Periodontitis is an inflammatory disease of the supporting tissues of the teeth caused by groups of specific microorganisms. The concept that localized problem sites may be treated by local drug delivery appears attractive as the antimicrobial agent is delivered within periodontal pockets and the therapy is targeted on specific pathogenic microorganisms. Local delivery of antimicrobial agents u...

The purpose of writing this review on gastroretentive drug delivery systems was to compile the recent literature with special focus on various gastroretentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug delivery. In order to understand various physiological difficulties to achieve gastric retention, we have...

We present the fabrication of nanoscale electroactive thin films that can be engineered to undergo remotely controlled dissolution in the presence of a small applied voltage (+1.25 V) to release precise quantities of chemical agents. These films, which are assembled by using a nontoxic, FDA-approved, electroactive material known as Prussian Blue, are stable enough to release a fraction of their...

Paclitaxel loaded cerasomes exhibited sophisticated controlled release behavior and remarkably high stability towards surfactant solubilization, long-term storage, acidic treatment, and all factors susceptible to destabilize conventional liposomes, demonstrating that liposomal nanohybrid cerasomes can be a new promising drug delivery system.

Considerable research efforts have been directed in recent years towards the development of porous carriers as controlled drug delivery matrices because of possessing several features such as stable uniform porous structure, high surface area, tunable pore size and well-defined surface properties. Owing to wide range of useful properties porous carriers have been used in pharmaceuticals for man...

Osmotic drug delivery mechanism is well known in the field of oral controlled release systems. The release of drug from the osmotic drug delivery devices is based on the phenomenon of osmosis. An useful technology developed for osmotic delivery of drug is asymmetric membrane capsule (AMC), which is an economic and effective drug delivery device as compared to other existing technique of osmotic...

This paper presents state-of-the-art micro and nano-fabrication techniques for biodegradable polymers. Replication molding, using a rigid or elastic master, can pattern structures on a polymer surface in a submicron resolution at a low cost. Layer-by-layer rapid prototyping methods are promising in producing controlled release units with complicated geometries, release mechanisms and the abilit...

We report a microfluidic approach to produce monodisperse pH-responsive microcapsules with precisely controlled release behavior. The solid microcapsule shells are composed of a biocompatible pH-responsive polymer and robustly encapsulate an active material; however, when exposed to a trigger pH, the shells degrade and ultimately release the microcapsule contents. We control the trigger pH by u...

The objective of this project is to introduce students to the concepts of diffusion, polymers and polymerization reactions, and enzyme mediated reactions by designing and testing a controlled release drug delivery system. These types of systems are also referred to as localized drug delivery because an implant that releases drugs is placed directly into diseased tissue. Here, we use Jell-O c ©a...