Goal-directed hand movements are guided by sensory information and may be adjusted 'online,' during the movement. If the target of a movement unexpectedly changes position, trajectory corrections can be initiated in as little as 100 ms in adults. This rapid visual online control is impaired in children with developmental coordination disorder (DCD), and potentially in other neurodevelopmental c...

The chemokine CX3CL1/fractalkine is expressed by neurons as a transmembrane-anchored protein that can be cleaved to yield a soluble isoform. However, the roles for these two types of endogenous CX3CL1 in neurodegenerative pathophysiology remain elusive. As such, it has been difficult to delineate the function of the two isoforms of CX3CL1, as both are natively present in the brain. In this stud...

Zolpidem, a non-benzodiazepine hypnotic, was identified in the blood of 29 subjects arrested for impaired driving. Zolpidem concentrations ranged from 0.05 to 1.4 mg/L (mean 0.29 mg/L, median 0.19 mg/L). In the subjects whose cases we reviewed where zolpidem was present with other drugs and/or alcohol, symptoms reported were generally those of CNS depression. Symptoms included slow movements an...

The chemokine CX3CL1/fractalkine is expressed by neurons as a transmembrane-anchored protein that can be cleaved to yield a soluble isoform. However, the roles for these two types of endogenous CX3CL1 in neurodegenerative pathophysiology remain elusive. As such, it has been difficult to delineate the function of the two isoforms of CX3CL1, as both are natively present in the brain. In this stud...

OBJECTIVES To examine different clinically relevant eligibility criteria sets to determine how they differ in numbers and characteristics of individuals served. DESIGN Cross-sectional analysis of the 2000 wave of the Health and Retirement Study (HRS), a nationally representative longitudinal health interview survey of adults aged 50 and older. SETTING Population-based cohort of community-dw...

Herb-drug interactions are an important safety concern and this study was conducted regarding the interaction between the natural top-selling antidepressant remedy Hypericum perforatum (Hypericaceae) and conventional drugs. This study examined the influence of acute pretreatment with different extracts of Hypericum perforatum from Serbia on pentobarbital-induced sleeping time, impairment of mot...

The concept of locally specialized functions dominates research on higher brain function and its disorders. Locally specialized functions must be complemented by processes that coordinate those functions, however, and impairment of coordinating processes may be central to some psychotic conditions. Evidence for processes that coordinate activity is provided by neurobiological and psychological ...

purpose: to determine the anatomical sites and causes of severe visual impairment (svi) and blindness in children attending a school for the blind in ahvaz. methods: in this case series study, all 51 students of the only school for the blind in ahvaz were examined by two ophthalmologists. blindness and svi were defined according to the world health organization (who) criteria as visual acuity l...

the aim of the study was to find whether there is an association between subjective memory complaint and memory impairment and probable underlying psychological conditions. a total of 90 patients with subjective memory complaint enrolled in this study. short history and demographic information were obtained and then the patients underwent memory and mental health assessments, using wechsler mem...

introduction: hearing impairment and hearing loss are kinds of latent handicap in children. any abnormality in hearing can affect different aspects of life. otoacoustic emissions have been accepted as an appropriate method for screening of hearing loss in neonates. in this study we assessed the hearing status of infants admitted in icu wards in yazd.materials and methods: this was a cross-secti...