BACKGROUND Currently, a constant shortage in the supply of platelets has become an important medical and society challenge, especially in developing country, and the in vitro production of megakaryocytic progenitor cells (MPs) from cord blood could represent an effective platelet substitute. In the present study, our objective was to determine the safety and feasibility of ex vivo generated MPs...

objective(s): umbilical cord blood is a good source of the mesenchymal stem cells that can be banked, expanded and used in regenerative medicine.  the objective of this study was to test whether amniotic membrane extract, as a rich source of growth factors such as basic-fibroblast growth factor, can promote the proliferation potential of the umbilical cord mesenchymal stem cells. materials and ...

background: hemoglobin (hb) and hematocrit (hct) have been used routinely in the diagnosis of neonatal anemia and polycythemia.   objective: to measure the cord blood hb and hct and to determine their association with maternal hb and hct.   methods : 170 healthy neonates born through normal vaginal delivery with gestation age of 37-42 wks and birth weight of 2.5-4 kg, and their mothers were inc...

Human placenta-derived mesenchymal stem cells (P-MSCs) have drawn increasing attention in the field of stem cell research due to their potential in clinical applications as well as their rich and easy to procure cell source. While studies demonstrating the potential of P-MSCs for therapeutic transplantations have been documented, a clinically compliant procedure for P-MSC expansion in vitro has...

background: hla compatibility between transplant donor and recipient is one of the major determinants of transplant outcome. objective: to determine hla class i by pcr- sequence-specific oligonucleotide probe (pcr-ssop) in cord blood donors. methods: genomic dna of 142 cord blood samples registered at the cord blood bank of iran at hematology, oncology, and bone marrow transplantation research ...

background: human umbilical cord blood (hucb) is an acceptable and readily accessible source of stem cells. there is an ongoing interest in cord blood stem cell therapies; however, little is known about the possible unfavorable effects of laboratory modifications on the isolated hucb cells. the involvement of mirnas in several biological processes has been shown. the aim of this study was to ev...

background: in recent years we have successfully adopted an in vitro hepatogenic differentiation of mesenchymal stem cells (mscs). in this protocol the biologically active hepatocyte-like cells were differentiated from the stem cells isolated from either bone marrow or umbilical cord blood (ucb) samples. the aim of the present study was to compare the efficiency of the hepatogenic differentiati...

a:4:{s:10:"Background";s:2314:"The research made on stem cells through the last decade and following that the great achievements made applying stem cells in treating vast number of diseases have turned the issue of Cord Blood collecting and saving (cryopreserving) to a critical one. A prompt demand and access to stem cells and applying them in treating a wide range of terminal diseases have led...