Traumatic brain injury (TBI) leading to 5 million deaths annually is 1 of the 5 major causes of morbidity and mortality worldwide. In Iran, accidents are the main cause of death in youth as well as a dominant factor in reducing quality of life. In developing countries TBI incidence as one of the worst consequences of these accidents is growing due to wide use of motor-vehicles. Therapeutic stra...

Umbilical cord blood (UCB) transplantation is being used as an alternative source of haematopoietic stem cells for bone marrow reconstitution. Umbilical cord blood (UCB) transplantation is being used as an alternative source of haematopoietic stem cells for bone marrow reconstitution. Separation and processing of UCB samples in large numbers for storage in cord blood banks ideally needs to be p...

Effect of graft source on unrelated donor haemopoietic stem-cell trans-plantation in adults with acute leukaemia: a retrospective analysis. al. Unrelated transplantation for poor-prognosis adult acute lym-phoblastic leukemia: long-term outcome analysis and study of the impact of hematopoietic graft source. R, et al. Favorable outcome of unrelated cord blood transplantation for Philadelphia chro...

post-remission treatment in patients with acute myeloid leukemia is still controversial. one potent choice for patients with no donor available is autologous stem cell transplantation. the median follow-up period was 18 months and the median age was 26 years old. in the review of 116 recently diagnosed aml patients (except aml- m3) who underwent autologous stem cell transplantation, 72.4% of pa...

in worldwide, an estimated 40 cases per 1 million people reported with new spinal cord injuries each year. people with spinal cord injuries suffer from severe physical, psychological, social and economic problems. damaged or lost cells can't be replaced when the spinal cord is injured; therefore, its function becomes disturbed permanently. despite the significant advances in the understand...

it was estimated that 3 million people suffered from spinal cord injury. unfortunately up to date, there are not any reliable clinical treatments for spinal cord injury and researches for treatments of sci have focused on medication, surgery, stem cell transplantation, molecular therapy and tissue engineering. also scientists are trying to use a combination of stem cells and nanotechnology scie...

Objective(s): Neurotrophic factors secreting cells (NTS-SCs) may be a superior cell source for cell-based therapy in neurodegenerative diseases. NTS-SCs are able to secrete some neurotrophic Such as nerve growth factor and glia-derived neurotrophic factor. Our primary aim was to assess transplantation of neurotrophic factor secreting cells derived from human adipose-derived stem cells (hADSCs) ...

BACKGROUND Diarrhea is a frequent complication of hematopoietic stem-cell transplantation (HSCT). Important causes of diarrhea after HSCT include acute graft-versus-host disease (GVHD), infections, and medications. After the transplantation and engraftment of hematopoietic stem cells from umbilical-cord blood, we observed a new syndrome of culture-negative, antibiotic-responsive diarrhea not at...