The Kv2.1 channel generates a delayed-rectifier current in neurons and is responsible for modulation of neuronal spike frequency and membrane repolarization in pancreatic β-cells and cardiomyocytes. As with other tetrameric voltage-activated K(+)-channels, it has been proposed that each of the four Kv2.1 voltage-sensing domains activates independently upon depolarization, leading to a final con...

Designing future computer networks dictates an eclectic vision capable of encompassing ideas and concepts developed in contemporary research unfettered by today’s operational and technological constraints. However, unguided by a clear articulation of core design principles, the process of network design may be at stake of falling into similar pitfalls and limitations attributed to current netwo...

In the present work, the inhibitory effect of carbon monoxide (CO), generated by tricarbonyldichlororuthenium (II) dimer [CO-releasing molecule (CORM-2)], on the toxicity of radiation-induced bystander effect (RIBE) after alpha-particle irradiation was studied in a mixed coculture system. CO (CORM-2) treatment showed a significant inhibitory effect to the formation of p53 binding protein 1 (BP1...

We examined our hypothesis that heme-oxygenase-1 (HO-1)-derived carbon monoxide (CO) inhibits the release of high-mobility group box 1 (HMGB1) in RAW264.7 cells activated with lipopolysaccharide (LPS) in vitro and in LPS- or cecal ligation and puncture (CLP)-induced septic mice in vivo, so that HO-1 induction or CO improves survival of sepsis in rodents. We found that pretreatment with HO-1 ind...

in order to investigation some soil characteristics and filed age effects on flower and corm yield of saffron, an experiment was conducted as factorial based on complete randomized design with five replications in two regions of neyshabur during growing season 2009-2010. treatments were included different filed ages (2, 4 and 6 years) and two geographical regions (eshagh abad and soltan abad). ...

OBJECTIVE The aim of this study was to observe the counter-effect of carbon monoxide-releasing molecule-2 (CORM-2) on lipopolysaccharide (LPS)-suppressed thrombomodulin (TM) and endothelial protein C receptor (EPCR) expressions from human umbilical vein endothelial cell (HUVEC), and to reveal its mechanisms. METHODS HUVECs were divided into 5 treatment groups, wherein reagents were added simu...

Tenascin-C (TN-C), an extracellular matrix (ECM) glycoprotein, is specifically induced upon tissue injury and infection and during septic conditions. Carbon monoxide (CO) gas is known to exert various anti-inflammatory effects in various inflammatory diseases. However, the mechanisms underlying the effect of CO on TN-C-mediated inflammation are unknown. In the present study, we found that treat...

Charlotte Sahlberg Bang (2016): Carbon monoxide and nitric oxide as antimicrobial agents -focus on ESBL-producing uropathogenic E. coli. Örebro Studies in Medicine 136. Urinary tract infections (UTI) are common in humans and most often caused by uropathogenic Escherichia coli (E. coli). Extended-spectrum beta-lactamase (ESBL)-producing E. coli are increasing worldwide and they are frequently mu...

in a field experiment, during three successive years of 2007, 2008 and 2009, the effects of planting pattern and high corm density on agronomic performance of saffron was investigated at the research station of ferdowsi university of mashhad. a complete randomized block design in a factorial arrangement of three replications being employed. treatments consisted of three corm rates of planting (...