PURPOSE To describe corneal endothelial cell density and morphology in the Indian population and to compare endothelial cell characteristics in the Indian population with data available in literature for American and Japanese populations. METHODS Specular microscopy and corneal pachymetry were performed in both eyes of 537 normal Indian volunteers, aged 20-87 years. Parameters studied include...

Pseudophakic bullous keratopathy is characterized by corneal stromal edema with epithelial and subepithelial bullae due to cell loss and endothelial decompensation through trauma during cataract surgery. Patients present decreased vision, tearing, and pain caused by ruptured epithelial bullae. Cataract affects approximately 20 million people worldwide, and this complication can occur in 1 to 2%...

PURPOSE Corneal endothelial cells (EC) are crucial for maintaining corneal clarity before and after keratoplasty. Since it is thought that corneal graft rejection leads to irreversible EC loss and transplant failure, we quantified immune mediated EC loss in the rat keratoplasty model and analyzed whether the EC layer would then regenerate. METHODS Rats were subjected to orthotopic penetrating...

PURPOSE To analyze early corneal endothelial cell loss due to microincision cataract surgery (MICS) in comparison with standard phacoemulsification through the temporal clear corneal incision. METHODS The examined group consisted of a nonrandomized, consecutive prospective series of 20 eyes of 20 patients who underwent uneventful microincision cataract surgery. Twenty eyes of 20 patients who ...

Bullous Keratopathy is the presence of corneal epithelial bullae, resulting from corneal endothelial disease. Bullous Keratopathy is caused by oedema of the cornea, resulting from failure of the corneal endothelium to maintain the normally dehydrated state of the cornea. Most frequently, it is due to Fuchs corneal endothelial dystrophy or corneal endothelial trauma. Fuchs dystrophy is a genetic...

Citation: Zhang W, Ogando DG, Kim ET, et al. Conditionally immortal Slc4a11 / mouse corneal endothelial cell line recapitulates disrupted glutaminolysis seen in Slc4a11 / mouse model. Invest Ophthalmol Vis Sci. 2017;58:3723–3731. DOI:10.1167/ iovs.17-21781 PURPOSE. To establish conditionally immortal mouse corneal endothelial cell lines with genetically matched Slc4a11þ/þ and Slc4a11 / mice as ...

PURPOSE To determine the viability and potential usefulness of cryopreserved human primary cultured corneal endothelial cells by characterizing their morphology, gene expression, and ability for genetic modification by the lentiviral vector equine infectious anemia virus (EIAV). METHODS Primary cultured endothelial cells were dissociated from human corneas and grown in organ culture medium. C...

BACKGROUND Our aim was to determine if there is a correlation between corneal biomechanical properties, endothelial cell count, and corneal pachymetry in healthy corneas. MATERIAL/METHODS Ninety-two eyes of all subjects underwent complete ocular examination, including intraocular pressure measurement by Goldmann applanation tonometer, objective refraction, and slit-lamp biomicroscopy. Topogra...

Introduction The phacoemulsification cataract surgery is the most frequently performed surgery and it generally improves vision in over 90% of the patients. Hyperopic patients are a challenge during phacoemulsification especially because of their short eyeball and shallow anterior chamber. A shallow anterior chamber is associated with overall reduction of the safe zone, which may lead to diffic...

AIM To compare corneal endothelial structure and central corneal thickness (CCT) between type II diabetics and non-diabetic control patients. To look for correlations between diabetic status and corneal findings. METHODS Hospital-based, observational study. 200 eyes (from 100 type II diabetic patients and 100 controls) were included. Specular microscopy and pachymetry were used to measure end...