Using a micropolarographic system, we measured the responses of six human corneas to nine oxygen exposure conditions: to air (continuous open-eye) with no contact lens in place, and to eight interblink intervals (1, 2, 3, 4, 5, 6, 7, and 300 s durations) with an oxygen impermeable lens in place. The corneal oxygen uptake rates immediately following each of those conditions were direct indices o...

PURPOSE To determine whether topical ocular delivery of <100 nm nanoparticles can be enhanced by coating their exterior with peptide or protein ligands for cell surface receptors. METHODS A novel ex vivo bovine eye model was validated for its integrity up to 60 min. Using this model, the uptake of 20 nm polystyrene nanoparticles (administered as a single 50 mul drop) before and after surface ...

In vitro transcorneal permeation of diclofenac from oil drops was studied using freshly excised goat cornea. The maximum apparent corneal permeability coefficient (Papp) was obtained with 0.2% (w/v) diclofenac drops in sesame oil followed by safflower oil, while formulation in castor oil provided minimal Papp. The addition of benzyl alcohol, a preservative, in oil drops, increased the Papp valu...

The effect of formulation factors on permeation of diclofenac from some experimental and marketed aqueous eye drops through excised goat cornea was evaluated. Raising the pH of formulation from 6.0 to 8.0 or diclofenac concentration from 0.05 to 0.15% (w/v) or adjusting tonicity with mannitol or addition of viscolizing agent decreased apparent permeability coefficient (Papp). Formulation (pH 7....

Fluorophotometry was carried out in nine cases of unilateral non-traumatic rhegmatogenous retinal detachment successfully treated by a combination of local buckling and an encircling procedure with a silicone band. After topical instillation of fluorescein the change in its concentration in the anterior chamber was followed, from which the loss rate of the dye from the anterior chamber (k0) and...

Dorzolamide ophthalmic drop is one of the most common glaucoma medications but it has a short residence time in the eye. The aim of this study is to develop ocular dorzolamide HCl nanoliposomes (DRZ – nanoliposomes) and to evaluate their potential use for the treatment of ocular hypertension. Nanoliposomes were prepared using Reverse-phase evaporation vesicle (REV) and thin layer hydration (TLH...

AIMS To further understand the morphological and functional recovery of corneal epithelium following excimer laser photorefractive keratectomy (PRK). METHODS The right eyes (group 1) of 15 male, New Zealand white rabbits weighing 2-3 kg underwent PRK. The left eye of each rabbit (group 2) underwent simple mechanical de-epithelialisation and were examined as treated controls. Both eyes of anot...

6-Aminohexanoic acid is a potent antifibrinolytic agent with the ability to retard dissolution of fibrin clots. The corneal penetration of 6-aminohexanoic acid was measured to determine if therapeutic levels of the drug could be maintained in the anterior chamber by topical administration. The conjunctival sac to anterior chamber transfer coefficient was found to be 1.51 X 10-4 +/- 0.20 X 10-4 ...